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Name |
Bumetanide |
EINECS | 249-004-6 |
CAS No. | 28395-03-1 | Density | 1.347 g/cm3 |
PSA | 127.10000 | LogP | 4.89060 |
Solubility | Soluble in ethanol (10 mg/ml), DMSO (25 mg/ml), acetone, benzene, methanol, propylene glycol, and water (<1 mg/ml). | Melting Point |
230-231 °C |
Formula | C17H20N2O5S | Boiling Point | 571.2 °C at 760 mmHg |
Molecular Weight | 364.422 | Flash Point | 299.3 °C |
Transport Information | N/A | Appearance | crystalline solid |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
Benzoicacid, 3-(butylamino)-4-phenoxy-5-sulfamoyl- (8CI);3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid;3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid;3-n-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid;Bumex;Burinex;Fontego;Fordiuran;Lixil;Lunetoron;PF1593;Ro 10-6338; |
Molecular Structure of Bumetanide (CAS NO.28395-03-1):
IUPAC Name: 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
Molecular Formula: C17H20N2O5S
Molecular Weight: 364.416100 g/mol
EINECS: 249-004-6
Melting Point: 230-231 °C
Density: 1.347 g/cm3
Flash Point: 299.3 °C
Enthalpy of Vaporization: 90.11 kJ/mol
Boiling Point: 571.2 °C at 760 mmHg
Vapour Pressure: 6.89E-14 mmHg at 25 °C
Water Solubility: 32.22 mg/L at 25 °C
Appearance: Crystalline Solid
Classification Code: Diuretic; Diuretics; Drug / Therapeutic Agent; Membrane Transport Modulators; Natriuretic Agents; Sodium Potassium Chloride Symporter Inhibitors
Bumetanide (CAS NO.28395-03-1) is used to treat heart failure. It is often used in patients in whom high doses of furosemide are ineffective with the brand name Bumex.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | > 500ug/kg (0.5mg/kg) | BEHAVIORAL: TETANY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 66, 1972. |
dog | LDLo | oral | > 500ug/kg (0.5mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 66, 1972. |
mammal (species unspecified) | LD50 | intravenous | 6200ug/kg (6.2mg/kg) | Journal of Clinical Pharmacology. Vol. 21, Pg. 543, 1981. | |
mouse | LD50 | intramuscular | > 25mg/kg (25mg/kg) | Yakkyoku. Pharmacy. Vol. 27, Pg. 1057, 1976. | |
mouse | LD50 | intraperitoneal | 519mg/kg (519mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976. | |
mouse | LD50 | intravenous | > 200mg/kg (200mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976. | |
mouse | LD50 | oral | 4624mg/kg (4624mg/kg) | Drugs in Japan Vol. 6, Pg. 683, 1982. | |
mouse | LD50 | subcutaneous | 1660mg/kg (1660mg/kg) | Drugs in Japan Vol. 6, Pg. 683, 1982. | |
rabbit | LD50 | intravenous | 70mg/kg (70mg/kg) | Postgraduate Medical Journal, Supplement. Vol. 51(Suppl, | |
rabbit | LD50 | oral | 350mg/kg (350mg/kg) | Postgraduate Medical Journal, Supplement. Vol. 51(Suppl, | |
rat | LD50 | intramuscular | > 5mg/kg (5mg/kg) | Yakkyoku. Pharmacy. Vol. 27, Pg. 1057, 1976. | |
rat | LD50 | intraperitoneal | 891mg/kg (891mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979. | |
rat | LD50 | intravenous | > 200mg/kg (200mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976. | |
rat | LD50 | oral | > 6gm/kg (6000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976. | |
rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976. |
Poison by ingestion, subcutaneous, and intravenous routes. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of SOx and NOx.
Safety Information of Bumetanide (CAS NO.28395-03-1):
WGK Germany: 3
RTECS: DG4910000
Bumetanide (CAS NO.28395-03-1), its Synonyms are Benzoicacid, 3-(butylamino)-4-phenoxy-5-sulfamoyl- (8CI) ; 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid ; 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid ; 3-n-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid ; Bufenox ; Bumex ; Burinex ; Edemex ; Fontego ; Fordiuran ; Lixil ; Lunetoron .