7530-31-6

Basic information

• Product Name: 2-Propenamide, N-(4-aminophenyl)-
• CAS NO: 7530-31-6
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.191
• Mol File: 7530-31-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, N-(4-aminophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, N-(4-aminophenyl)-(7530-31-6)
• EPA Substance Registry System: 2-Propenamide, N-(4-aminophenyl)-(7530-31-6)

Safety Data

• Hazardous Substances Data: 7530-31-6(Hazardous Substances Data)

Usage

Description

2-Propenamide, N-(4-aminophenyl)-, also known as Acrylamide with a phenyl and amino group, is a chemical compound with the molecular formula C9H10N2O. It is an amide derivative characterized by the presence of a phenyl substituent and an amino group attached to the acrylamide backbone. This versatile chemical is known for its potential applications in various fields, including polymer and plastic production, pharmaceutical and agricultural chemical synthesis, dye and pigment manufacturing, and as a precursor in other chemical reactions. Its unique structure and properties have also attracted interest in the realms of organic chemistry and materials science research.

Uses

Used in Polymer and Plastics Industry:
2-Propenamide, N-(4-aminophenyl)is utilized as a monomer in the production of various polymers and plastics. Its ability to form co-polymers with other compounds contributes to the development of materials with tailored properties for specific applications.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-Propenamide, N-(4-aminophenyl)serves as an intermediate in the synthesis of various drugs. Its reactivity and functional groups make it a valuable component in the creation of new medicinal compounds.
Used in Agricultural Chemicals:
2-Propenamide, N-(4-aminophenyl)is also employed in the synthesis of agricultural chemicals, where it can be used to develop new pesticides or other agrochemicals that improve crop yields and protect plants from diseases and pests.
Used in Dyes and Pigments Industry:
2-Propenamide, N-(4-aminophenyl)is used in the manufacturing of dyes and pigments, where its chemical structure allows for the production of a wide range of colors and shades for various applications, including textiles, paints, and inks.
Used in Organic Chemistry Research:
In the field of organic chemistry, 2-Propenamide, N-(4-aminophenyl)is studied for its potential as a precursor in various chemical reactions, providing insights into new synthetic pathways and the development of novel organic compounds.
Used in Materials Science Research:
2-Propenamide, N-(4-aminophenyl)-'s unique structure and properties make it a subject of interest in materials science, where it can be explored for its potential to contribute to the development of new materials with specific characteristics, such as improved conductivity, strength, or other desirable properties.

Upstream product

• 79-10-7 acrylic acid 
• 106-50-3 1,4-phenylenediamine 
• 100-01-6 4-nitro-aniline 
• 814-68-6 acryloyl chloride 
• 71026-66-9 N-(tert-butoxycarbonyl)-1,4-phenylenediamine 
• 7766-38-3 N-(4-nitrophenyl) acrylamide 
• 100-25-4 para-dinitrobenzene 
• 7439-89-6 iron 

Downstream Products

• 473430-67-0 N-{4-[4-(3,4,5-trimethoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-phenyl}-acrylamide 
• 1374640-70-6 (N-(3-(2-(4-(4-acetylpiperazin-1-yl)-2-methoxyphenylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)phenyl)acrylamide) 
• 1357381-90-8 pyrrolidine-1-carboxylic acid (4-acryloylaminophenyl)-amide 

Relevant articles and documents

Discriminating detection of multiple analytes (F- and CN-) by a single probe through colorimetric and fluorescent dual channels

Abstract Two novel Schiff base type receptors containing phenol hydroxyl group (1) or methoxy group (2) were designed and synthesized. The receptor 1 with phenol hydroxyl group exhibited different colorimetric and fluorimetric responses to fluoride and cy

Design, synthesis and structure-activity relationship of diaryl-ureas with novel isoxazol[3,4-b]pyridine-3-amino-structure as multi-target inhibitors against receptor tyrosine kinase

Inspired by that the multi-target inhibitors against receptor tyrosine kinases (RTKs) have significantly improved the effect of clinical treatment for cancer, and based on the chemical structure of Linifanib (ABT-869, Abbott), two series of diaryl-ureas with novel isoxazol[3,4-b]pyridine-3-amino-structure were designed and synthesized as multi-target inhibitors against RTKs. The preliminary biological evaluation showed that several compounds exhibited comparable potency with Linifanib. Compound S21 was identified as the most potent inhibitor against Fms-like tyrosine kinase 3 (FLT-3), kinase insert domain containing receptor (KDR) and platelet-derived growth factor receptor β (PDGFR-β) with its IC50 values were 4 nM, 3 nM and 8 nM respectively, it also showed potent inhibitory activities against several cancer cells.

Synthesis of thermo- and photo-responsive polysiloxanes with tunable phase separation: Via aza-Michael addition

Two kinds of thermo- and photo-dual-responsive polysiloxanes (DRPSs) with functional pendent groups, N-isopropyl amides and azobenzene (Azo) or salicylideneaniline (SA), were synthesized through a facile, effective, and catalyst-free aza-Michael addition of poly(aminopropylmethyl-siloxane) with N-isopropyl acrylamide and N-azobenzene acrylamide or N-salicylaldehyde acrylamide. The chemical structrures of DRPSs were systematically characterized using FT-IR, H NMR and UV-Vis spectroscopy. The as-prepared DRPSs with lower Azo or SA contents exhibited lower critical solution temperature (LCST)-type phase transition in water, which is reversible and can be controlled by temperature and UV light. The effects of Azo and SA contents on the responsive properties of DRPSs are examined in detail. The LCST decreased with the increasing Azo or SA content. Once the content of Azo or SA reached up to 5.7% or 8.2%, respectively, DRPSs could not be dissolved in water even in an ice bath. Higher values of the LCST were measured after irradiation of the polymer solutions due to the higher polarity of cis-Azo and keto-SA conformation, induced by irradiation. The differences in cloud points between the irradiated and the non-irradiated DRPS aqueous solutions increased up to 3.4 °C and 9.8 °C when combined with 3.8% Azo and 5.8% SA units, respectively.

TANK-BINDING KINASE INHIBITOR COMPOUNDS

Compounds having the following formula (I) and methods of their use and preparation are disclosed: