Molecules p. 19 - 35 (2009)
Update date:2022-09-26
Topics: Synthesis Purification and characterization Biological Assays Clinical Trials Lead Optimization Design Regulatory Approval Structure-Activity Relationship (SAR) Preclinical Testing Pharmacokinetics and Pharmacodynamics Toxicity and Selectivity Rationale
Dude, Marie-Adrienne
Kaeppler, Ulrich
Herb, Monika
Schiller, Markus
Schulz, Franziska
Vedder, Birgit
Heppner, Saskia
Pradel, Gabriele
Gut, Jiri
Rosenthal, Philip J.
Schirmeister, Tanja
Leippe, Matthias
Gelhaus, Christoph
A series of etacrynic acid derivatives was synthesized and screened for their in vitro activity against Plasmodium falciparum, as well as their activity against recombinantly expressed falcipain-2 and -3. The two most active compounds of the series displayed IC50 values of 9.0 and 18.8 μM against Plasmodia.
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Doi:10.1021/jo00367a031
(1986)Doi:10.1055/s-2008-1042921
(2008)Doi:10.1021/ml1002458
(2011)Doi:10.1016/j.ica.2011.06.036
(2011)Doi:10.1248/cpb.33.2838
(1985)Doi:10.1016/S0040-4020(01)82095-0
(1986)