(1-Bromocyclopentyl)(2-chlorophenyl)methanone

Base Information Edit

Chemical Name:(1-Bromocyclopentyl)(2-chlorophenyl)methanone
CAS No.:6740-86-9
Molecular Formula:C12H12 Br Cl O
Molecular Weight:287.584
Hs Code.:2914700090
European Community (EC) Number:229-803-6
DSSTox Substance ID:DTXSID40986677
Nikkaji Number:J298.095I
Wikidata:Q82974681
Mol file:6740-86-9.mol

Synonyms:(1-bromocyclopentyl)(2-chlorophenyl)methanone;6740-86-9;(1-bromocyclopentyl)-(2-chlorophenyl)methanone;EINECS 229-803-6;1-Bromocyclopentyl-o-chlorophenyl ketone;EC 229-803-6;C12H12BrClO;(1-Bromocyclopentyl)(2-chlorophenyl) ketone;C12-H12-Br-Cl-O;SCHEMBL3660666;DTXSID40986677;MFCD19303925;AS-0811;FT-0774567;EN300-300949

Suppliers and Price of (1-Bromocyclopentyl)(2-chlorophenyl)methanone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Bromocyclopentyl2-ChlorophenylKetone
500mg
$ 595.00

Crysdot
(1-Bromocyclopentyl)(2-chlorophenyl)methanone 95+%
5g
$ 377.00

Alichem
(1-Bromocyclopentyl)(2-chlorophenyl)methanone
10g
$ 639.18

Total 67 raw suppliers

Chemical Property of (1-Bromocyclopentyl)(2-chlorophenyl)methanone Edit

Chemical Property:

Vapor Pressure:0.000257mmHg at 25°C
Boiling Point:323.7°C at 760 mmHg
Flash Point:149.6°C
PSA：17.07000
Density:1.509g/cm³
LogP:4.23040
Storage Temp.:Refrigerator, Under inert atmosphere
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)
XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:285.97601
Heavy Atom Count:15
Complexity:248

Purity/Quality:

99.9% ^*data from raw suppliers

1-Bromocyclopentyl2-ChlorophenylKetone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(C1)(C(=O)C2=CC=CC=C2Cl)Br
Uses 1-Bromocyclopentyl 2-Chlorophenyl Ketone is a reactant in the dehydrohalogenation of axial 6-bromoketamine III and is also an intermediate in the synthesis of S-(-)-Norketamine (N692060).

Technology Process of (1-Bromocyclopentyl)(2-chlorophenyl)methanone

There total 6 articles about (1-Bromocyclopentyl)(2-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 6740-85-8
(2-chlorophenyl)(cyclopentyl)methanone

: 6740-86-9
(1-Bromocyclopentyl)(2-chlorophenyl)methanone

Guidance literature:: With copper(ll) bromide; In ethyl acetate; at 77 ℃;
DOI:10.1021/acs.orglett.7b02177

Reference yield:

: 873-32-5
2-Chlorobenzonitrile

: 6740-86-9
(1-Bromocyclopentyl)(2-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium; iodine / diethyl ether / 1 h

1.2: 16 h

2.1: N-Bromosuccinimide; toluene-4-sulfonic acid / dichloromethane / 6 h

With N-Bromosuccinimide; iodine; toluene-4-sulfonic acid; magnesium; In diethyl ether; dichloromethane;
DOI:10.1124/dmd.113.051631

Reference yield:

: 609-65-4
o-chlorobenzoyl chloride

: 6740-86-9
(1-Bromocyclopentyl)(2-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: Cyclopentane; aluminum (III) chloride / dichloromethane / -10 °C / Inert atmosphere; Reflux

2: hydrogen bromide; dihydrogen peroxide / water / 3 h / 70 - 80 °C

With aluminum (III) chloride; Cyclopentane; hydrogen bromide; dihydrogen peroxide; In dichloromethane; water; 1: |Nenitzescu Synthesis;
DOI:10.1021/acs.oprd.9b00553