(Diethylamino)acetone

Base Information

• Chemical Name: (Diethylamino)acetone
• CAS No.: 1620-14-0
• Molecular Formula: C7H15 N O
• Molecular Weight: 129.202
• Hs Code.: 29223900
• European Community (EC) Number: 216-583-1
• NSC Number: 61985
• DSSTox Substance ID: DTXSID20167280
• Nikkaji Number: J80.262J
• Mol file: 1620-14-0.mol

Synonyms:Diethylaminoacetone;(Diethylamino)acetone;1620-14-0;1-(diethylamino)propan-2-one;2-Propanone, 1-(diethylamino)-;N,N-Diethylaminoacetone;EINECS 216-583-1;AI3-24553;NSC61985;1-diethylaminopropan-2-one;1-(Diethylamino)acetone #;1-diethylamino-propan-2-one;(Diethylamino)acetone, 96%;SCHEMBL442212;DTXSID20167280;ADAL1185391;BAA62014;NSC 61985;NSC-61985;AKOS005188291;FT-0604909;FT-0624877;E83834;J-009885

Chemical Property of (Diethylamino)acetone

Chemical Property:

• Vapor Pressure: 1.64mmHg at 25°C
• Refractive Index: n20/D 1.425(lit.)
• Boiling Point: 168.2°Cat760mmHg
• PKA: 8.47±0.25(Predicted)
• Flash Point: 38.3°C
• PSA: 20.31000
• Density: 0.87g/cm³
• LogP: 0.91720
• Storage Temp.: 0-6°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 86.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

Diethylaminoacetone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,C
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCN(CC)CC(=O)C

Technology Process of (Diethylamino)acetone

There total 10 articles about (Diethylamino)acetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethylamine (109-89-7) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 1-(diethylamino)propan-2-one (1620-14-0)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; at 160 ℃; for 36h; Inert atmosphere; Sealed tube;

Reference yield: 80.0%

N,N-diethyl-1,1-dimethyl-1-(prop-1-en-2-yloxy)silanamine (5573-55-7) → 1-(diethylamino)propan-2-one (1620-14-0)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; at 25 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201400405

Reference yield: 65.0%

diethylamine (109-89-7) + chloroacetone (78-95-5) → 1-(diethylamino)propan-2-one (1620-14-0)

Guidance literature:

In diethyl ether; for 24h; Reflux;

DOI:10.1016/j.tetasy.2009.03.014

upstream raw materials:

N,N-diethyl-2-propynylamine

propargyl alcohol

diethylamine

chloroacetone

Downstream raw materials:

1-diethylamino-2-methyl-4-phenyl-butan-2-ol

9-methylphenanthrene

1-N,N-diethylamino-2-aminopropane

1-diethylamino-2-propanol

Refernces

• 1、 -. "Preparation method of N-acetonyl amine compound". Paragraph 0046. . Retrieved 2016/10/09.
• 2、 Kosmalski, Tomasz,Wojtczak, Andrzej,Zaidlewicz, Marek. "Asymmetric synthesis of β-dialkylamino alcohols by transfer hydrogenation of α-dialkylamino ketones". experimental part. p. 1138 - 1143. Retrieved 2009/09/27.