(2-Bromophenyl)methylazanium;chloride

Base Information

• Chemical Name: (2-Bromophenyl)methylazanium;chloride
• CAS No.: 5465-63-4
• Molecular Formula: C7H8 Br N . Cl H
• Molecular Weight: 222.512
• Hs Code.: 2921499090
• Mol file: 5465-63-4.mol

Synonyms:

Chemical Property of (2-Bromophenyl)methylazanium;chloride

Chemical Property:

• Appearance/Colour: WHITE TO TAN POWDER, CRYSTALS, CRYSTALLINE POWDER AND/OR CHUNKS
• Vapor Pressure: 0.0321mmHg at 25°C
• Melting Point: 227-230 ºC
• Boiling Point: 243.5 °C at 760 mmHg
• Flash Point: 101 °C
• PSA: 26.02000
• LogP: 3.41010
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• Solubility.: Soluble in methanol (25 mg/ml).
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 220.96069
• Heavy Atom Count: 10
• Complexity: 85

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromobenzylamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C[NH3+])Br.[Cl-]
• Uses: It is employed as an intermediate in organic syntheses.

Technology Process of (2-Bromophenyl)methylazanium;chloride

There total 4 articles about (2-Bromophenyl)methylazanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

o-cyanobromobenzene (2042-37-7) → 2-bromobenzylamine hydrochloride (5465-63-4)

Guidance literature:

o-cyanobromobenzene; With [2,6-η6:η1-bis(2,4,6-trimethylphenyl)phenylthiolato]triethylphosphineruthenium(II)tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; diethylphenylsilane; at 20 ℃; for 18h; Glovebox; Inert atmosphere;

With hydrogenchloride; In diethyl ether; at 20 ℃; for 1h; Glovebox; Inert atmosphere;

DOI:10.1055/s-0036-1588441

Reference yield: 91.0%

1-(2-bromobenzyl)-3,4-diphenyl-1H-pyrrole-2,5-dione → 2-bromobenzylamine hydrochloride (5465-63-4)

Guidance literature:

1-(2-bromobenzyl)-3,4-diphenyl-1H-pyrrole-2,5-dione; With water; sodium hydroxide; In ethanol; at 105 ℃; for 0.133333h; Microwave irradiation;

With hydrogenchloride;

Reference yield: 85.0%

1-bromo-2-(nitromethyl)benzene (854634-26-7) → 2-bromobenzylamine hydrochloride (5465-63-4)

Guidance literature:

1-bromo-2-(nitromethyl)benzene; With C₃₆H₅₆Cl₃CrN₂O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere; Schlenk technique;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; at 20 ℃; chemoselective reaction;

DOI:10.1021/jacs.0c12318

upstream raw materials:

o-cyanobromobenzene

2-Bromobenzamide

1-bromo-2-(nitromethyl)benzene

Downstream raw materials:

o-cyanobromobenzene

2-bromo-N,N-dimethylbenzylamine

N-(2-bromobenzyl)-4-methylbenzenesulfonamide

N-(2-bromo)benzyl picolinamide

Refernces

• 1、 Bhunia, Mrinal,Sahoo, Sumeet Ranjan,Das, Arpan,Ahmed, Jasimuddin,Sreejyothi,Mandal, Swadhin K.. "Transition metal-free catalytic reduction of primary amides using an abnormal NHC based potassium complex: Integrating nucleophilicity with Lewis acidic activation". . p. 1848 - 1854. Retrieved 2020/03/03.
• 2、 -. "A method for the production of primary amines". Paragraph 0202; 0203. . Retrieved 2016/10/09.