Tritylamine

Base Information

• Chemical Name: Tritylamine
• CAS No.: 5824-40-8
• Molecular Formula: C19H17N
• Molecular Weight: 259.351
• Hs Code.: 29214990
• European Community (EC) Number: 628-686-2
• NSC Number: 1154
• UNII: UR7TF3NW3P
• DSSTox Substance ID: DTXSID30206972
• Nikkaji Number: J150.550E
• Wikidata: Q72515514
• Pharos Ligand ID: X91X2TGALPU8
• ChEMBL ID: CHEMBL272255
• Mol file: 5824-40-8.mol

Synonyms:triphenylmethylamine;tritylamine

Chemical Property of Tritylamine

Chemical Property:

• Appearance/Colour: white to light yellow powder
• Vapor Pressure: 1.2E-05mmHg at 25°C
• Melting Point: 102-104 °C(lit.)
• Refractive Index: 1.7500 (estimate)
• Boiling Point: 369.3 °C at 760 mmHg
• PKA: 7.77±0.10(Predicted)
• Flash Point: 190.9 °C
• PSA: 26.02000
• Density: 1.096 g/cm³
• LogP: 4.63750
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Air Sensitive
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility.: Insoluble
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 259.136099547
• Heavy Atom Count: 20
• Complexity: 235

Purity/Quality:

99% ^*data from raw suppliers

Triphenylmethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N
• Uses: Triphenylmethylamine is a trityl derivative that is structurally related to Clotrimazole (C587400). Triphenylmethylamine is used in the preparation of trityl-cysteine analogs as inhibitors of human mi totic kinesin. Triphenylmethylamine is also used as a fireproofing agent. Triphenylmethylamine a trityl derivative that is structurally related to Clotrimazole (C587400) (2). Triphenylmethylamine is used in the preparation of trityl-cysteine analogs as inhibitors of human mitotic kinesin (1) . Triphenylmethylamine was used to prepare diamondoid porous organic salt. It was also used in preparation of N-tritylated β-aminoalcohols, useful building blocks in organic synthesis.

Technology Process of Tritylamine

There total 35 articles about Tritylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trityl chloride (76-83-5) → Triphenylmethylamin (5824-40-8)

Guidance literature:

With ammonium hydroxide; at 20 - 35 ℃; for 2h;

Reference yield: 95.0%

trityl azide (14309-25-2) → Triphenylmethylamin (5824-40-8)

Guidance literature:

With 1,3-diadamantane-4,5-dihydroimidazole chloride; potassium tert-butylate; bis(pinacol)diborane; copper(l) chloride; In toluene; at 25 ℃; for 4h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2020.151702

Reference yield: 90.0%

bromo-triphenyl-methane (596-43-0) → Triphenylmethylamin (5824-40-8)

Guidance literature:

With ammonia;

upstream raw materials:

bromo-triphenyl-methane

Phenyl-trityl-amine

ammonium acetate

bromo-trityl-amine

Downstream raw materials:

chloro-acetic acid tritylamide

N-allyl-N'-trityl-thiourea

N-Isopropylidenaminooxymethyl-N'-triphenylmethyl-harnstoff

N-(triphenylmethyl)methanimine

Refernces

• 1、 -. "Synthetic method of 3-hydroxyazetidine hydrochloride". Paragraph 0065-0069. . Retrieved 2020/11/05.
• 2、 Chen, Yang,Deng, Shengqi,Gao, Yihua,Liu, Liwen,Liu, Yu,Lu, Da,Wang, Qianwen,Zhang, Xiao. "Copper catalyzed reduction of azides with diboron under mild conditions". supporting information. . Retrieved 2020/02/27.