2-(Ethylthio)ethylamine

Base Information

• Chemical Name: 2-(Ethylthio)ethylamine
• CAS No.: 36489-03-9
• Molecular Formula: C4H11NS
• Molecular Weight: 105.204
• Hs Code.: 29309090
• European Community (EC) Number: 626-572-7
• DSSTox Substance ID: DTXSID30189993
• Nikkaji Number: J264.865B
• Wikidata: Q83062235
• Mol file: 36489-03-9.mol

Synonyms:2-(Ethylthio)ethylamine;36489-03-9;2-(Ethylthio)ethanamine;2-ethylsulfanylethanamine;2-(ethylsulfanyl)ethan-1-amine;2-[Ethylthio]ethylamonium;2-(ethylsulfanyl)ethanamine;Ethanamine, 2-(ethylthio)-;2-Aminoethylethyl sulfide;MFCD00014826;2-ethylthioethylamine;2-ethylthio-ethylamine;[2-(ethylthio)ethyl]amine;2-(ethylsulfanyl)ethylamine;SCHEMBL152661;2-(Ethylthio)ethylamine, 96%;DTXSID30189993;BBL104215;STL558079;AKOS000172300;MS-20057;FT-0611245;EN300-213208;F77934;F2147-1017

Chemical Property of 2-(Ethylthio)ethylamine

Chemical Property:

• Appearance/Colour: Clear colorless liquid
• Vapor Pressure: 1.7mmHg at 25°C
• Melting Point: 163 °C
• Refractive Index: n20/D 1.4900
• Boiling Point: 167.4 °C at 760 mmHg
• PKA: 9.04±0.10(Predicted)
• Flash Point: 55.1 °C
• PSA: 51.32000
• Density: 0.937 g/cm³
• LogP: 1.39850
• Sensitive.: Stench
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 105.06122053
• Heavy Atom Count: 6
• Complexity: 23.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Ethylthio)ethylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCSCCN

Technology Process of 2-(Ethylthio)ethylamine

There total 6 articles about 2-(Ethylthio)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

ethyl bromide (74-96-4) + 2-mercaptoethylamine hydrochloride (156-57-0) → 2-(ethylthio)ethylamine hydrochloride (36489-03-9)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 24h;

DOI:10.1002/bkcs.12341

Reference yield: 60.0%

ethyl iodide (75-03-6) + Cysteamine (60-23-1) → 2-(ethylthio)ethylamine hydrochloride (36489-03-9)

Guidance literature:

Cysteamine; With potassium hydroxide; In ethanol; at 20 ℃; for 1h; Inert atmosphere;

ethyl iodide; In ethanol; at 0 ℃; for 3h; Inert atmosphere; Reflux;

DOI:10.1002/zaac.201300066

Reference yield:

ethyleneimine (151-56-4,9002-98-6) + ethanethiol (75-08-1) → 2-(ethylthio)ethylamine hydrochloride (36489-03-9)

Guidance literature:

With methanol;

upstream raw materials:

ethyleneimine

ethanethiol

sulfuric acid mono-(2-amino-ethyl ester)

ethyl iodide

Downstream raw materials:

N-(2-(diphenylphosphino)benzylidene)-2-(ethylthio)ethanamine

C₂₄H₂₆ClF₃N₄O₂S

3-(2-(ethylthio)ethylamino)-N-(3-ethynylphenyl)propanamide

2-(2-(ethylthio)ethylamino)-N-(3-ethynylphenyl)acetamide

Refernces

• 1、 Choi, Jieun,Lee, Hyung-il. "Thermoresponsive Sulfone and Sulfoxide-Containing Polyacrylamides". supporting information. p. 1143 - 1150. Retrieved 2021/06/17.