Technology Process of Irenolone
There total 7 articles about Irenolone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1: 1.) 2,3-dichloro-5,6-dicyano-p-benzoquinone / 1.) ether, reflux, 3 h, 2.) CH2Cl2, reflux, 3 h
2: 1.) DIBAH, 2.) Jones reagent / 1.) toluene, -78 deg C, 4 h, 2.) acetone, room temp., 15 min
3: 70percent t-butyl-hydroperoxide, 40percent benzyltrimethylammonium hydroxide / benzene / Ambient temperature
4: p-toluenesulfonic acid / CH2Cl2 / 2 h
5: 100 percent / boron tribromide / CH2Cl2 / 0.25 h
With
tert.-butylhydroperoxide; jones reagent; boron tribromide; N-benzyl-trimethylammonium hydroxide; diisobutylaluminium hydride; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)85707-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) DIBAH, 2.) Jones reagent / 1.) toluene, -78 deg C, 4 h, 2.) acetone, room temp., 15 min
2: 70percent t-butyl-hydroperoxide, 40percent benzyltrimethylammonium hydroxide / benzene / Ambient temperature
3: p-toluenesulfonic acid / CH2Cl2 / 2 h
4: 100 percent / boron tribromide / CH2Cl2 / 0.25 h
With
tert.-butylhydroperoxide; jones reagent; boron tribromide; N-benzyl-trimethylammonium hydroxide; diisobutylaluminium hydride; toluene-4-sulfonic acid;
In
dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)85707-0