5-Bromo-2-iodophenol

Base Information

• Chemical Name: 5-Bromo-2-iodophenol
• CAS No.: 858855-11-5
• Molecular Formula: C6H4BrIO
• Molecular Weight: 298.906
• Hs Code.: 2908199090
• Mol file: 858855-11-5.mol

Synonyms:Phenol, 5-bromo-2-iodo-;

Chemical Property of 5-Bromo-2-iodophenol

Chemical Property:

• Melting Point: 55 °C
• Boiling Point: 239.4±20.0 °C(Predicted)
• PKA: 7.55±0.10(Predicted)
• PSA: 20.23000
• Density: 2.369±0.06 g/cm3(Predicted)
• LogP: 2.75930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-bromo-2-iodophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-iodophenol

There total 3 articles about 5-Bromo-2-iodophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-bromo-1-iodo-2-methoxybenzene (791642-68-7) → 5-bromo-2-iodo-phenol (858855-11-5)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1021/acs.joc.8b00146

Reference yield: 71.0%

2-amino-5-bromophenol (38191-34-3) → 5-bromo-2-iodo-phenol (858855-11-5)

Guidance literature:

2-amino-5-bromophenol; With boron trifluoride diethyl etherate; In tetrahydrofuran; at -40 - -30 ℃; for 0.166667h; Inert atmosphere;

With tert.-butylnitrite; In tetrahydrofuran; at -30 - 20 ℃; for 1.5h; Inert atmosphere;

With iodine; potassium iodide; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;

Reference yield: 47.0%

3-Bromophenol (591-20-8) → 5-bromo-2-iodo-phenol (858855-11-5)

Guidance literature:

With potassium iodate; sulfuric acid; potassium iodide; In water; at 20 ℃; for 18h;

DOI:10.3762/bjoc.10.297

upstream raw materials:

2-amino-5-bromophenol

3-Bromophenol

4-bromo-1-iodo-2-methoxybenzene

Downstream raw materials:

2,3,4,6-tetrabromophenol

Refernces

• 1、 Jiang, Nianqiang,Yuan, Ziyong,Li, Tao,Zhu, Yanpeng,Chen, Yu-Sheng,Lin, Liqiong,Zhang, Jingrui,Chan, Yi-Tsu,Wang, Jiaobing. "Synthesis and Characterization of Ferrocene Based Hemicages". . p. 4824 - 4830. Retrieved 2018.