3,3-AZETIDINEDIMETHANOL HYDROCHLORIDE

Base Information

• Chemical Name: 3,3-AZETIDINEDIMETHANOL HYDROCHLORIDE
• CAS No.: 1016232-92-0
• Molecular Formula: C5H12ClNO2
• Molecular Weight: 153.609
• Mol file: 1016232-92-0.mol

Synonyms:3,3-AZETIDINEDIMETHANOL HYDROCHLORIDE;[3(hydroxyMethyl)azetidin3yl]Methanol hydrochloride;Azetidine-3,3-diyldimethanol hydrochloride;3,3-Azetidinedimethanol HCl

Chemical Property of 3,3-AZETIDINEDIMETHANOL HYDROCHLORIDE

Chemical Property:

• PSA: 52.49000
• LogP: -0.30860

Purity/Quality:

NLT 98% ^*data from raw suppliers

[3-(Hydroxymethyl)azetidin-3-yl]methanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3-AZETIDINEDIMETHANOL HYDROCHLORIDE

There total 3 articles about 3,3-AZETIDINEDIMETHANOL HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

azetidine-3,3-dimethanol (45512-27-4) → azetidine-3,3-dimethanol hydrochloride (1016232-92-0)

Guidance literature:

Reference yield:

N-benzyl-3,3-bis-(hydroxymethyl)-azetidine (26096-30-0) → azetidine-3,3-dimethanol hydrochloride (1016232-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium(II) hydroxide/carbon / methanol / 20 °C

With hydrogen; palladium(II) hydroxide/carbon; In methanol;

Reference yield:

3,3‐diethyl 1‐benzylazetidine‐3,3‐dicarboxylate (642411-11-8) → azetidine-3,3-dimethanol hydrochloride (1016232-92-0)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

2: hydrogen / palladium(II) hydroxide/carbon / methanol / 20 °C

With lithium aluminium tetrahydride; hydrogen; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol;

upstream raw materials:

azetidine-3,3-dimethanol

N-benzyl-3,3-bis-(hydroxymethyl)-azetidine

3,3‐diethyl 1‐benzylazetidine‐3,3‐dicarboxylate

Downstream raw materials:

1-[(7-benzyloxymethyl-4-tert-butoxy-9-deazapurin-9-yl)methyl]azetidine-3,3-dimethanol

Refernces