2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid

Base Information

• Chemical Name: 2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid
• CAS No.: 2800-34-2
• Molecular Formula: C20H23 N7 O7
• Molecular Weight: 473.445
• Mol file: 2800-34-2.mol

Synonyms:Glutamicacid, N-[p-[N-[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-(7CI); Glutamic acid,N-[p-[N-[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-,L- (8CI); L-Glutamic acid,N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-(9CI); 10-Formyl-(6RS)-tetrahydrofolic acid; 10-Formyl-5,6,7,8-tetrahydrofolicacid; 10-Formyltetrahydrofolate; 10-Formyltetrahydrofolic acid;10-Formyltetrahydropteroylglutamic acid; N10-Formyl-5,6,7,8-tetrahydrofolicacid; N10-Formyltetrahydrofolate; N10-Formyltetrahydrofolic acid;N10-Formyltetrahydropteroylglutamate

Chemical Property of 2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid

Chemical Property:

• PKA: 3.42±0.10(Predicted)
• PSA: 219.84000
• Density: 1.68±0.1 g/cm3(Predicted)
• LogP: 1.15290

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 10-Formyl-5,6,7,8-tetrahydro Folic Acid is a Folic Acid (F680300) derivative. Folic Acid is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.

Technology Process of 2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid

There total 2 articles about 2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N10-formylfolic acid (134-05-4) → 10-formyltetrahydrofolate (2800-34-2)

Guidance literature:

With platinum; Hydrogenation;

DOI:10.1021/ja01133a014 DOI:10.1021/ja01151a074 DOI:10.1021/ja01151a028

Reference yield:

tetrahydrofolic acid (135-16-0) + formic acid (64-18-6) → 10-formyltetrahydrofolate (2800-34-2)

Guidance literature:

DOI:10.1021/ja01133a014 DOI:10.1021/ja01151a074 DOI:10.1021/ja01151a028

Reference yield:

10-formyltetrahydrofolate (2800-34-2) + 1-methyl-4-nitrosobenzene (623-11-0) → folinic acid (58-05-9,22350-60-3,54353-24-1,68538-85-2,73951-54-9)

Guidance literature:

DOI:10.1021/ja01133a014 DOI:10.1021/ja01151a074 DOI:10.1021/ja01151a028

upstream raw materials:

tetrahydrofolic acid

formic acid

N¹⁰-formylfolic acid

Downstream raw materials:

folinic acid