Technology Process of (4S,6R)-4-hydroxy-14-methyl-1,2,5,6-tetrahydro-4a,11b-(epiminoethano)-4,6-epoxyphenanthro[2,3-d][1,3]dioxol-3(4H)-one
There total 5 articles about (4S,6R)-4-hydroxy-14-methyl-1,2,5,6-tetrahydro-4a,11b-(epiminoethano)-4,6-epoxyphenanthro[2,3-d][1,3]dioxol-3(4H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
water;
at 50 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jo401889b
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / ethanol / 0.25 h / 0 °C / Inert atmosphere
2: hydrogenchloride / water / 4 h / 75 °C / Inert atmosphere
3: sodium ethanolate / ethanol / 0.33 h / 75 °C / Inert atmosphere
4: hydrogenchloride / water / 4 h / 50 °C / Inert atmosphere
With
hydrogenchloride; sodium tetrahydroborate; sodium ethanolate;
In
ethanol; water;
DOI:10.1021/jo401889b
- Guidance literature:
-
Multi-step reaction with 5 steps
1: formic acid / Inert atmosphere
2: sodium tetrahydroborate / ethanol / 0.25 h / 0 °C / Inert atmosphere
3: hydrogenchloride / water / 4 h / 75 °C / Inert atmosphere
4: sodium ethanolate / ethanol / 0.33 h / 75 °C / Inert atmosphere
5: hydrogenchloride / water / 4 h / 50 °C / Inert atmosphere
With
hydrogenchloride; sodium tetrahydroborate; formic acid; sodium ethanolate;
In
ethanol; water;
DOI:10.1021/jo401889b