1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Base Information Edit

Chemical Name:1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.:64544-07-6
Molecular Formula:C20H22N4O10S
Molecular Weight:510.481
Hs Code.:2941906000
European Community (EC) Number:638-760-6
NCI Thesaurus Code:C28918
NSC Number:758677
RXCUI:20493
Wikipedia:Cefuroxime_axetil
Mol file:64544-07-6.mol

1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Synonyms:acetoxyethylcefuroxime;CCI 15641;CCI-15641;Ceftin;Cefurax;cefuroxime 1-acetoxyethyl ester;cefuroxime axetil;Cepazine;Cetoxil;Curocef;Elobact;Novador;Novocef;Oraxim;Zinat;Zinnat

Suppliers and Price of 1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Cefuroxime Axetil
2.5g
$ 820.00

Sigma-Aldrich
Cefuroxime Axetil European Pharmacopoeia (EP) Reference Standard
c0694990
$ 190.00

Sigma-Aldrich
Cefuroxime Axetil mixture of isomers, analytical standard
10mg
$ 66.50

Sigma-Aldrich
Cefuroxime Axetil United States Pharmacopeia (USP) Reference Standard
350mg
$ 366.00

Sigma-Aldrich
Cefuroxime Axetil ≥98% (HPLC)
100mg
$ 364.00

ChemScene
Cefuroxime Axetil 98.99%
100mg
$ 270.00

ChemScene
Cefuroxime Axetil 98.99%
25mg
$ 95.00

ChemScene
Cefuroxime Axetil 98.99%
50mg
$ 160.00

AvaChem
Cefuroxime Axetil
10g
$ 875.00

AvaChem
Cefuroxime Axetil
100mg
$ 75.00

Total 156 raw suppliers

Chemical Property of 1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Edit

Chemical Property:

Appearance/Colour:white to pale yellow powder
Melting Point:175-180 °C
Refractive Index:1.665
Boiling Point:250°C (rough estimate)
PKA:8.31±0.60(Predicted)
PSA：214.36000
Density:1.61 g/cm³
LogP:0.86080
Storage Temp.:?20°C
Solubility.:DMSO: soluble1mg/mL
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:12
Exact Mass:510.10566408
Heavy Atom Count:35
Complexity:968

Purity/Quality:

99% up, ^*data from raw suppliers

Cefuroxime Axetil ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(OC(=O)C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CC=CO3)COC(=O)N
Isomeric SMILES:CC(OC(=O)C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)/C(=N/OC)/C3=CC=CO3)COC(=O)N
Recent ClinicalTrials:Does Antibiotic Prophylaxis at Urinary Catheter Removal Prevent Urinary Tract Infections
Recent EU Clinical Trials:Short course antibiotic treatment of Gram-negative bacteremia: A multicenter, randomized, non-blinded, non-inferiority interventional study
Uses Cefuroxime 1-acetoxyethyl ester is an injectable second generation cephalosporin with an excellent antibacterial activity. This ester has a broader spectrum of activity than cephalexin (first-generation) and is widely used to treat respiratory tract infections. It is the 1-(acetyloxy) ethyl ester of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester has a broader spectrum of activity than cephalexin (first-generation) and is widely used to treat respiratory tract infections. Antibacterial. antiviral (opthalmic)

Technology Process of 1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

There total 7 articles about 1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%