Loprodiol

Base Information Edit

Chemical Name:Loprodiol
CAS No.:2209-86-1
Molecular Formula:C5H10 Cl2 O2
Molecular Weight:173.039
Hs Code.:2905590090
European Community (EC) Number:218-635-9
NSC Number:21467
UNII:U1K5BS2ABA
DSSTox Substance ID:DTXSID40176591
Nikkaji Number:J7.361J
Wikidata:Q27290562
NCI Thesaurus Code:C66033
ChEMBL ID:CHEMBL2105828
Mol file:2209-86-1.mol

Synonyms:Loprodiol;Dispranol;2209-86-1;Chlorpropandiol;2,2-bis(chloromethyl)propane-1,3-diol;Clorpropandiol;Pentaerythritol dichlorohydrin;Loprodiol [INN];2,2-Bis(chloromethyl)-1,3-propanediol;1,3-Propanediol, 2,2-bis(chloromethyl)-;Loprodiolum [INN-Latin];NSC-21467;U1K5BS2ABA;EINECS 218-635-9;NSC 21467;BRN 1698883;AI3-15943;pentaerythritol dichloride;Loprodiolum;UNII-U1K5BS2ABA;WLN: Q1X1Q1G1G;SCHEMBL380993;1, 2,2-bis(chloromethyl)-;CHEMBL2105828;DTXSID40176591;CHEBI:134807;CAA20986;NSC21467;AKOS006273702;PENTAERYTHRITOL DICHLOROHYDRIN [MI];LS-120179;1,3-Propanediol, 2,2-bis(chloro-methyl)-;4-01-00-02553 (Beilstein Handbook Reference);SR-01000945269;SR-01000945269-1;Q27290562

Suppliers and Price of Loprodiol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2,2-BIS(CHLOROMETHYL)PROPANE-1,3-DIOL 95.00%
5MG
$ 495.10

Total 8 raw suppliers

Chemical Property of Loprodiol Edit

Chemical Property:

Vapor Pressure:8.73E-06mmHg at 25°C
Melting Point:79-80° (uncorr), 83° (corr), also reported as 65° and 95°
Refractive Index:1.4595 (estimate)
Boiling Point:334.9°Cat760mmHg
PKA:13.63±0.10(Predicted)
Flash Point:156.3°C
PSA：40.46000
Density:1.342g/cm³
LogP:0.43500
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:172.0057849
Heavy Atom Count:9
Complexity:67.4

Purity/Quality:

99% ^*data from raw suppliers

2,2-BIS(CHLOROMETHYL)PROPANE-1,3-DIOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(C(CO)(CCl)CCl)O

Technology Process of Loprodiol

There total 10 articles about Loprodiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

: 2210-05-1
5,5-dichloromethyl-2-thia-1,3-dioxane 2-oxide

: 2209-86-1
2,2-bis(chloromethyl)-1,3-propanediol

Guidance literature:: With hydrogenchloride; In water; benzene; for 2h; Heating;

Reference yield: 28.0%

: 78-71-7,25323-58-4
3,3-bis(chloromethyl)oxetane

: 2209-86-1
2,2-bis(chloromethyl)-1,3-propanediol

Guidance literature:: With sulfuric acid; In water;
DOI:10.1007/BF00771773

Reference yield:

: 115-77-5
Pentaerythritol

: 2209-86-1
2,2-bis(chloromethyl)-1,3-propanediol

: 3228-99-7
pentaerythrityl tetrachloride

: 813-99-0
3-chloro-(2,2-chloromethyl)propan-1-ol

Guidance literature:: With pyridine; thionyl chloride; for 14h; Yield given. Yields of byproduct given; Heating;
DOI:10.1016/S0022-1139(00)80471-6