N-Methyl-1-naphthalenemethylamine hydrochloride

Base Information

• Chemical Name: N-Methyl-1-naphthalenemethylamine hydrochloride
• CAS No.: 65473-13-4
• Molecular Formula: C12H13N^.HCl
• Molecular Weight: 207.703
• Hs Code.: 29214990
• European Community (EC) Number: 613-801-0
• UNII: Z8VRT9B309
• DSSTox Substance ID: DTXSID00215793
• Wikidata: Q27295156
• Mol file: 65473-13-4.mol

Synonyms:65473-13-4;N-Methyl-1-naphthalenemethylamine hydrochloride;N-Methyl-1-(naphthalen-1-yl)methanamine hydrochloride;N-Methyl-1-naphthylmethylamine Hydrochloride;N-Methyl-N-naphthylmethylamine hydrochloride;MFCD00012555;N-Methyl-1-naphthalenemethanamine hydrochloride;1-[(Methylamino)methyl]naphthalene hydrochloride;1-Naphthalenemethanamine, N-methyl-, hydrochloride (1:1);Z8VRT9B309;N-Methyl(1-naphthylmethyl)amine hydrochloride;N-Methyl-C-(naphthalen-1-yl)methanamine hydrochloride;N-METHYL-1-NAPHTHALENEMETHYLAMINE, HCL;methyl[(naphthalen-1-yl)methyl]amine hydrochloride;N-Methyl-C-(naphthalen-1-yl)methanamine Hydrochloride (Secondary Amine Hydrochloride);EN300-43430;UNII-Z8VRT9B309;1-Naphthalenemethanamine, N-methyl-, hydrochloride;N-methyl-1-naphthalen-1-ylmethanamine;hydrochloride;EC 613-801-0;SCHEMBL1093699;DTXSID00215793;AMY16807;STR05882;AKOS015900390;n-methyl-1-naphthalenemethyl amine hcl;AB01101;AC-5794;CS-W015253;N-Methyl-1-(1-naphthyl)methanamine HCl;N-Methyl-1-(Aminomethyl)naphthalene HCl;N-methyl-naphthylmethylamine hydrochloride;SY036923;N-METHYL-1-NAPHTHYLMETHYL AMINE HCL;M0984;NS00078395;1-(Methylaminomethyl)naphthalene Hydrochloride;N-(1-Naphthylmethyl)methylamine hydrochloride;D77775;N-Methyl-1-Naphthalenemethyl amine hydrochloride;A835129;N-Methyl-1-(1-naphthyl)methanamine Hydrochloride;A1-01693;J-523640;N-Methyl-1-(naphthalen-1-yl)methanamne hydrochlorde;N-Methyl-1-(naphthalen-1-yl)methanaminehydrochloride;N-Methyl-1-naphthalenemethylamine hydrochloride, 98%;Q27295156;Z445129424

Chemical Property of N-Methyl-1-naphthalenemethylamine hydrochloride

Chemical Property:

• Appearance/Colour: off-white powder
• Vapor Pressure: 0.00242mmHg at 25°C
• Melting Point: 191-193 °C(lit.)
• Boiling Point: 287.9 °C at 760 mmHg
• Flash Point: 146.7 °C
• PSA: 12.03000
• Density: 1.05g/cm
• LogP: 3.75210
• Storage Temp.: Indoors
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 207.0814771
• Heavy Atom Count: 14
• Complexity: 155

Purity/Quality:

99% ^*data from raw suppliers

N-(1-Naphthylmethyl)methylaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC1=CC=CC2=CC=CC=C21.Cl
• Uses: N-Methyl-1-naphthalenemethanamine hydrochloride is an intermediate used in the synthesis of various pharmaceuticals such as Terbinafine hydrochloride (T107500) and Butenafine hydrochloride (B690195). N-Methyl-1-naphthalenemethanamine hydrochloride (Terbinafine BP Impurity A; Terbinafine USP Related Compound A) is an intermediate used in the synthesis of various pharmaceuticals such as Terbinafine hydrochloride (T107500) and Butenafine hydrochloride (B690195).

Technology Process of N-Methyl-1-naphthalenemethylamine hydrochloride

There total 1 articles about N-Methyl-1-naphthalenemethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-methyl-1-naphthalenecarboxamide (3400-33-7) → N-methyl-1-naphthalenemethylamine hydrochloride (65473-13-4)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In benzene; below 60 deg C;

DOI:10.1002/ardp.19933260607

Reference yield: 94.0%

N-methyl-1-naphthalenemethylamine hydrochloride (65473-13-4) + 1-(bromomethyl)-4-(1,1-dimethylethyl)benzene (18880-00-7) → butenafine

Guidance literature:

With sodium carbonate; In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Reference yield: 88.0%

N-methyl-1-naphthalenemethylamine hydrochloride (65473-13-4) + 1-allyl-4-(4-chloro-phenyl)-1H-pyrrole-3-carboxylic acid (191668-34-5) → 1-allyl-4-(4-chloro-phenyl)-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide (191667-82-0)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

N-methyl-1-naphthalenecarboxamide

Downstream raw materials:

1-methyl-4-phenyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

4-(4-chloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

4-phenyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

4-p-tolyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

Refernces