Teichomycin

Base Information

• Chemical Name: Teichomycin
• CAS No.: 61036-62-2
• Molecular Formula: C77H77N9O31Cl2^.R
• Molecular Weight: 1879.66000
• Hs Code.: 2941900000
• Wikipedia: Teicoplanin
• Mol file: 61036-62-2.mol

Synonyms:Targocid;Teichomycin;Teichomycin A2;Teicoplanin

Chemical Property of Teichomycin

Chemical Property:

• Appearance/Colour: White powder
• Melting Point: 310 °C (decomp)
• Refractive Index: 1.76
• PSA: 662.41000
• Density: 1.69g/cm3
• LogP: 4.61850
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble10mg/mL
• Water Solubility.: Sparingly soluble in water
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 24
• Hydrogen Bond Acceptor Count: 34
• Rotatable Bond Count: 20
• Exact Mass: 1877.5565820
• Heavy Atom Count: 132
• Complexity: 3920

Purity/Quality:

98%, ^*data from raw suppliers

Teicoplanin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCC(=O)NC1C(C(C(OC1OC2=C3C=C4C=C2OC5=C(C=C(C=C5)C(C6C(=O)NC(C7=C(C(=CC(=C7)O)OC8C(C(C(C(O8)CO)O)O)O)C9=C(C=CC(=C9)C(C(=O)N6)NC(=O)C4NC(=O)C1C2=CC(=CC(=C2)OC2=C(C=CC(=C2)C(C(=O)NC(CC2=CC(=C(O3)C=C2)Cl)C(=O)N1)N)O)O)O)C(=O)O)OC1C(C(C(C(O1)CO)O)O)NC(=O)C)Cl)CO)O)O
• Isomeric SMILES: CCCCCCCCCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC2=C3C=C4C=C2OC5=C(C=C(C=C5)[C@H]([C@H]6C(=O)N[C@H](C7=C(C(=CC(=C7)O)O[C@@H]8[C@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C9=C(C=CC(=C9)[C@H](C(=O)N6)NC(=O)[C@@H]4NC(=O)[C@@H]1C2=CC(=CC(=C2)OC2=C(C=CC(=C2)[C@@H](C(=O)N[C@H](CC2=CC(=C(O3)C=C2)Cl)C(=O)N1)N)O)O)O)C(=O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)NC(=O)C)Cl)CO)O)O
• Recent EU Clinical Trials: Liverpool Pharmacokinetic/pharmacodynamics study of teicoplanin in children (LIPSTIC).
• Description: Teicoplanin is a new antibiotic, the second glycopeptide to be developed in over 30 years. Compared with vancomycin, the only such agent currently available, teicoplanin is equiefficacious, and has milder side-effects and a longer half-life, allowing once-daily dosing and bolus injection. Teicoplanin is claimed to have an overall cure rate of 92% in infections involving skin, joint and bone, endocaditis and septicemia.
• Uses: anticonvulsant, antipsychotic Teicoplanin complex is family of closely related metabolites produced by Actinoplanes teichomyceticus. Teicoplanin complex possesses potent broad spectrum antibiotic activity against Gram positive bacteria, including MRSA and E. faecalis. The metabolites share a common glycopeptide core (teicoplanin A-3) on which a family of fatty acids varying in length, degree of saturation and branching are linked as amides through one of the aminoglycoside moieties. The major component of the complex is teicoplanin A2 which itself has five major components (teicoplanin A2-1 to A2-5) and four minor components (teicoplanin RS-1 to RS-4). antidepressant
• Clinical Use: Antibacterial agent.
• Drug interactions: Potentially hazardous interactions with other drugs None known