2-Bromo-5-methylaniline

Base Information

• Chemical Name: 2-Bromo-5-methylaniline
• CAS No.: 53078-85-6
• Molecular Formula: C7H8 Br N
• Molecular Weight: 186.051
• Hs Code.: 29214300
• European Community (EC) Number: 628-662-1
• Nikkaji Number: J3.020.235J
• Mol file: 53078-85-6.mol

Synonyms:2-Bromo-5-methylaniline;53078-85-6;2-Bromo-5-methylbenzenamine;2-bromo-5-methylphenylamine;53078-35-6;Benzenamine, 2-bromo-5-methyl-;2-bromo-5-methyl-phenylamine;3-AMINO-4-BROMOTOLUENE;2-BROMO-5-METHYL ANILINE;MFCD01806278;2-bromo-5-methyl-aniline;6-BROMO-M-TOLUIDINE;SCHEMBL178557;2-Bromo-5-methylaniline, 97%;AKOS005133614;AB09930;AC-3717;CS-W007555;PS-5668;SY019865;AM20060658;B4507;FT-0649604;EN300-54643;A19786;W-203005

Chemical Property of 2-Bromo-5-methylaniline

Chemical Property:

• Appearance/Colour: COLORLESS TO BROWN LIQUID
• Vapor Pressure: 0.0249mmHg at 25°C
• Melting Point: 46°C
• Refractive Index: n20/D 1.603
• Boiling Point: 247.9oC at 760 mmHg
• PKA: 2.66±0.10(Predicted)
• Flash Point: 110 ºC
• PSA: 26.02000
• Density: 1.486 g/mL at 25 ºC
• LogP: 2.92090
• Storage Temp.: 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 184.98401
• Heavy Atom Count: 9
• Complexity: 94.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-5-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38-20/21/22
• Safety Statements: 9-26-36/37-60

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)Br)N

Technology Process of 2-Bromo-5-methylaniline

There total 9 articles about 2-Bromo-5-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Bromo-3-nitrotoluene (5326-34-1) → 2-bromo-5-methylaniline (53078-85-6)

Guidance literature:

With formic acid; triethylamine; platinum on carbon; at 100 ℃; for 12.3333h;

Reference yield: 94.0%

→ 2-bromo-5-methylaniline (53078-85-6)

Guidance literature:

Reference yield: 92.0%

4-bromo-2-nitrotoluene (60956-26-5) → 2-bromo-5-methylaniline (53078-85-6)

Guidance literature:

With ammonium chloride; iron; In water; for 48h; Heating / reflux;

upstream raw materials:

4-Bromo-3-nitrotoluene

N-(2-bromo-5-methylphenyl)acetamide

hydrogenchloride

4-methyl-2-nitroacetanilide

Downstream raw materials:

3,4-dibromotoluene

2-bromo-5-methylphenol

2-bromo-5-methylbenzylnitrile

N-(2-bromo-5-methylphenyl)acetamide

Refernces

• 1、 Ghosh, Sourav,Jagirdar, Balaji R.. "A capping agent dissolution method for the synthesis of metal nanosponges and their catalytic activity towards nitroarene reduction under mild conditions". . p. 17401 - 17411. Retrieved 2019/01/03.
• 2、 -. "MK2 INHIBITORS AND USES THEREOF". Paragraph 001109. . Retrieved 2014/10/03.