(R)-(-)-4-Methyl-2-pentanol

Base Information

• Chemical Name: (R)-(-)-4-Methyl-2-pentanol
• CAS No.: 16404-54-9
• Molecular Formula: C6H14O
• Molecular Weight: 102.177
• Hs Code.: 29051990
• European Community (EC) Number: 624-275-7
• Nikkaji Number: J1.194.348I
• Mol file: 16404-54-9.mol

Synonyms:16404-54-9;(R)-(-)-4-Methyl-2-pentanol;(2R)-4-methylpentan-2-ol;(R)-4-Methylpentan-2-ol;(R)-4-Methyl-2-pentanol;4-methyl (r)-2-pentanol;(2R)-4-methyl-2-pentanol;(r)-(-)-methylpentan-2-ol;SCHEMBL1090210;2-Pentanol,4-methyl-,(2R)-;(R)-(-)-4-Methylpentan-2-ol;2-Pentanol, 4-methyl-, (2R)-;MFCD03093077;AKOS006341992;AS-59602;D97159;EN300-1841931;A810530;A929769;J-010108;(R)-(-)-4-Methyl-2-pentanol, 97%, optical purity99% (ee) (GLC)

Chemical Property of (R)-(-)-4-Methyl-2-pentanol

Chemical Property:

• Appearance/Colour: Clear colorless liquid
• Refractive Index: n20/D 1.4630(lit.)
• Boiling Point: 133.5 °C at 760 mmHg
• PKA: 15.31±0.20(Predicted)
• Flash Point: 41.1 °C
• PSA: 20.23000
• Density: 0.811 g/cm³
• LogP: 1.41330
• Storage Temp.: Flammables area
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 102.104465066
• Heavy Atom Count: 7
• Complexity: 41.4

Purity/Quality:

99% ^*data from raw suppliers

(R)-(-)-4-METHYL-2-PENTANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 10-37-66-20
• Safety Statements: 24/25-46

MSDS Files:

Useful:

• Canonical SMILES: CC(C)CC(C)O
• Isomeric SMILES: C[C@H](CC(C)C)O
• Uses: For synthesis of optically active products

Technology Process of (R)-(-)-4-Methyl-2-pentanol

There total 16 articles about (R)-(-)-4-Methyl-2-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-methyl-2-pentanone (108-10-1) → (S)-4-methylpentan-2-ol (14898-80-7,72847-31-5) + (R)-4-methylpentan-2-ol (16404-54-9,72847-31-5)

Guidance literature:

With methanesulfonic acid; (R,R)-dihydroborate; In pentane; at -20 ℃; for 48h; Title compound not separated from byproducts;

DOI:10.1021/ja00283a042

Reference yield: 60.0%

→ (R)-4-methylpentan-2-ol (16404-54-9,72847-31-5)

Guidance literature:

Reference yield:

(R)-2,3-Dimethylbutylamin (74669-70-8) → 2-methylpentan-2-ol (590-36-3) + 2-methyl-3-pentanol (565-67-3) + 2,3-dimethylbutanol (19550-30-2,20281-85-0) + (R)-4-methylpentan-2-ol (16404-54-9,72847-31-5) + 2,3-dimethylbutan-2-ol (594-60-5) + (2S,3R)-(+)-3-methylpentan-2-ol (205698-03-9)

Guidance literature:

With sodium nitrite; In perchloric acid; water; for 72h; Product distribution; Mechanism;

upstream raw materials:

Methyl isobutyl carbinol

(E)-4-methylpent-2-ene

(SS)-4-methyl-1-(N-methylphenylsulfonimidoyl)-2-pentanol

(R)-2,3-Dimethylbutylamin

Downstream raw materials:

(+)-1,3-Dimethylbutyl-methacrylat

C₁₆H₂₀FNO₂

C₁₆H₂₀FNO₂

Refernces

• 1、 Pa?a, Salih,Arslan, Nevin,Meri??, Nermin,Kayan, Cezmi,Bingül, Murat,Durap, Feyyaz,Aydemir, Murat. "Boron containing chiral Schiff bases: Synthesis and catalytic activity in asymmetric transfer hydrogenation (ATH) of ketones". . . Retrieved 2019/09/19.
• 2、 Kilic, Ahmet,Balci, Tu?ba Ersayan,Arslan, Nevin,Aydemir, Murat,Durap, Feyyaz,Okumu?, Veysi,Tekin, Recep. "Synthesis of cis-1,2-diol-type chiral ligands and their dioxaborinane derivatives: Application for the asymmetric transfer hydrogenation of various ketones and biological evaluation". . . Retrieved 2020/06/10.