Sligkv-NH2

Base Information

• Chemical Name: Sligkv-NH2
• CAS No.: 190383-13-2
• Molecular Formula: C₂₈H₅₄N₈O₇
• Molecular Weight: 614.786
• DSSTox Substance ID: DTXSID70440595
• Nikkaji Number: J1.062.873C
• Wikidata: Q82256944
• ChEMBL ID: CHEMBL4084322
• Mol file: 190383-13-2.mol

Synonyms:Ser-Leu-Ile-Gly-Lys-Val-NH2;seryl-leucyl-isoleucyl-glycyl-lysyl-valinamide;SLIGKV-NH2

Chemical Property of Sligkv-NH2

Chemical Property:

• PSA: 260.86000
• LogP: 1.77930
• Storage Temp.: −20°C
• Solubility.: ≥13.48 mg/mL in EtOH with gentle warming and ultrasonic; ≥62.9 mg/mL in DMSO; ≥66.2 mg/mL in H2O
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 21
• Exact Mass: 614.41154609
• Heavy Atom Count: 43
• Complexity: 931

Purity/Quality:

98%,99%, ^*data from raw suppliers

SLIGKV-NH2 ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)C(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CO)N
• Isomeric SMILES: CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)N
• Uses: SLIGKV-NH2 is a PAR2 agonist.

Technology Process of Sligkv-NH2

There total 1 articles about Sligkv-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-Val-OH (68858-20-8) + Fmoc-Leu-OH (35661-60-0) + Fmoc-Ile-OH (71989-23-6,251316-98-0) → SLIGKV-NH2 (190383-13-2)

Guidance literature:

Fmoc-Val-OH; With piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; N,N-dimethyl-formamide; for 0.333333h;

With 4,6-dithiocyano-5-nitropyrimidine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Leu-OH; Fmoc-Ile-OH; Fmoc-Lys(pg)-OH; Fmoc-Ser(pg)-OH; Further stages;

DOI:10.1021/acs.orglett.1c04258

upstream raw materials:

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Val-OH

Fmoc-Leu-OH

Fmoc-Ile-OH

Refernces