HYDROXYETHYLTHIAMINE HYDROCHLORIDE

Base Information

• Chemical Name: HYDROXYETHYLTHIAMINE HYDROCHLORIDE
• CAS No.: 14707-32-5
• Molecular Formula: C₁₄H₂₁N₄O₂S*ClH*Cl
• Molecular Weight: 381.326
• Mol file: 14707-32-5.mol

Synonyms:3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-2-(1-hydroxyethyl)-5-(2-hydroxyethyl)-4-methylthiazoliumchloride, hydrochloride (6CI,7CI); Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-2-(1-hydroxyethyl)-5-(2-hydroxyethyl)-4-methyl-,chloride, monohydrochloride (8CI,9CI); 2-(1-Hydroxyethyl)thiamine chloridehydrochloride; DL-2-(a-Hydroxyethyl)thiamine chloride hydrochloride

Chemical Property of HYDROXYETHYLTHIAMINE HYDROCHLORIDE

Chemical Property:

• Melting Point: 218℃approximate 217℃
• PSA: 124.38000
• LogP: -0.95180

Purity/Quality:

98%min ^*data from raw suppliers

rac-2-(1-Hydroxyethyl)thiamineChlorideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: rac-2-(1-Hydroxyethyl)thiamine Chloride Hydrochloride is used in analytical studies for fluorometric determination of free thiamine in individual rat brain tissues.

Technology Process of HYDROXYETHYLTHIAMINE HYDROCHLORIDE

There total 4 articles about HYDROXYETHYLTHIAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

Thiamine hydrochloride (67-03-8,70732-86-4) + acetaldehyde (75-07-0,9002-91-9) → 2-(1-Hydroxyethyl)-thiamin hydrochloride (14707-32-5)

Guidance literature:

DOI:10.1039/b206765j

Reference yield:

4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide (2908-71-6) → 2-(1-Hydroxyethyl)-thiamin hydrochloride (14707-32-5)

Guidance literature:

With N,N-dimethyl-formamide; anschliessend Behandeln mit wss. HCl und Isopropylalkohol;

DOI:10.1021/ja01554a078

Reference yield:

1-[6a-adamantan-1-yldisulfanyl-3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-3a-methyl-hexahydro-furo[2,3-d]thiazol-2-yl]-ethanol (70732-87-5) → 2-(1-Hydroxyethyl)-thiamin hydrochloride (14707-32-5)

Guidance literature:

With hydrogenchloride; In methanol; Ambient temperature;

DOI:10.1002/jlcr.2580150134

upstream raw materials:

1-[6a-adamantan-1-yldisulfanyl-3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-3a-methyl-hexahydro-furo[2,3-d]thiazol-2-yl]-ethanol

4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide

Thiamine hydrochloride

acetaldehyde

Refernces

• 1、 Hayashi,Kato. "Radiolysis and synthesis of [N-methylene-3H]thiamine 1-adamantyl trisulfide hydrochloride". . p. 279 - 294. Retrieved 1978.