NAcSer(OBzl)DAsp(OBzl)Lys(Z)ProOBzl

Base Information

• Chemical Name: NAcSer(OBzl)DAsp(OBzl)Lys(Z)ProOBzl
• CAS No.: 127129-86-6
• Molecular Formula: C₄₉H₅₇N₅O₁₁
• Molecular Weight: 892.018
• Mol file: 127129-86-6.mol

Synonyms:NAcSer(OBzl)DAsp(OBzl)Lys(Z)ProOBzl

Chemical Property of NAcSer(OBzl)DAsp(OBzl)Lys(Z)ProOBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NAcSer(OBzl)DAsp(OBzl)Lys(Z)ProOBzl

There total 2 articles about NAcSer(OBzl)DAsp(OBzl)Lys(Z)ProOBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-Acetylimidazole (2466-76-4) + (S)-1-{(S)-2-[(R)-2-((S)-2-Amino-3-benzyloxy-propionylamino)-3-benzyloxycarbonyl-propionylamino]-6-benzyloxycarbonylamino-hexanoyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with trifluoro-acetic acid → NAcSer(OBzl)DAsp(OBzl)Lys(Z)ProOBzl (127129-86-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00170a012

Reference yield:

BocS(OBzl)-D-D(OBzl)K(Z)P-OBzl (127103-29-1) → NAcSer(OBzl)DAsp(OBzl)Lys(Z)ProOBzl (127129-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / Ambient temperature

2: 84 percent / triethylamine / dimethylformamide / Ambient temperature

With triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00170a012

Reference yield:

NAcSer(OBzl)DAsp(OBzl)Lys(Z)ProOBzl (127129-86-6) → AcSDDKP (127103-11-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00170a012

upstream raw materials:

N-Acetylimidazole

BocS(OBzl)-D-D(OBzl)K(Z)P-OBzl

Downstream raw materials:

AcSDDKP

Refernces