C₆₀H₉₉NO₁₃Si

Base Information

• Chemical Name: C₆₀H₉₉NO₁₃Si
• CAS No.: 151122-98-4
• Molecular Formula: C₆₀H₉₉NO₁₃Si
• Molecular Weight: 1070.53
• Mol file: 151122-98-4.mol

Synonyms:C₆₀H₉₉NO₁₃Si

Chemical Property of C₆₀H₉₉NO₁₃Si

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₆₀H₉₉NO₁₃Si

There total 2 articles about C₆₀H₉₉NO₁₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

triisopropylsilyl trifluoromethanesulfonate (80522-42-5) + sirolimus (53123-88-9) → C60H99NO13Si (151122-98-4)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃;

DOI:10.1021/ja963067o

Reference yield: 11.0%

C60H99NO13Si → C60H99NO13Si (151122-98-4) + C60H99NO13Si

Guidance literature:

With titanium(IV) trichloride isopropoxide; triethylamine; In dichloromethane; at -78 ℃;

DOI:10.1021/ja00073a083

Reference yield: 94.0%

t-butyldimethylsiyl triflate (69739-34-0) + C60H99NO13Si (151122-98-4) → C66H113NO13Si2 (186417-28-7)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃;

DOI:10.1021/ja963067o

upstream raw materials:

triisopropylsilyl trifluoromethanesulfonate

sirolimus

Downstream raw materials:

C₆₃H₁₀₇NO₁₃Si₂

sirolimus

C₆₆H₁₁₃NO₁₃Si₂

Refernces

• 1、 Hayward,Yohannes,Danishefsky. "Total synthesis of rapamycin via a novel titanium-mediated aldol macrocyclization reaction". . p. 9345 - 9346. Retrieved 2007/10/02.