4-amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide

Base Information

• Chemical Name: 4-amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide
• CAS No.: 1668-63-9
• Molecular Formula: C₈H₁₂ClN₃O₄S₂
• Molecular Weight: 313.786
• Mol file: 1668-63-9.mol

Synonyms:4-amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide

Chemical Property of 4-amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide

Chemical Property:

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide

There total 4 articles about 4-amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloraminophenamide (121-30-2) → 4-amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide (1668-63-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1 h / 180 °C

2: NaH / dimethylformamide / 1 h / 70 °C

3: aq. NaOH / Heating

With sodium hydroxide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/ja01490a028

Reference yield:

6-chloro-3,4-dihydro-3-oxo-2H-1,2,4-benzothiadiazine-7-sulfonamide,1,1-dioxide (89813-56-9) → 4-amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide (1668-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 1 h / 70 °C

2: aq. NaOH / Heating

With sodium hydroxide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/ja01490a028

Reference yield:

6-chloro-2-ethyl-1,1,3-trioxo-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide (99282-67-4) → 4-amino-6-chloro-benzene-1,3-disulfonic acid 1-amide 3-ethylamide (1668-63-9)

Guidance literature:

With sodium hydroxide; Heating;

DOI:10.1021/ja01490a028

upstream raw materials:

chlorothiazide

orthoformic acid triethyl ester

6-chloro-2-ethyl-1,1,3-trioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

chloraminophenamide

Downstream raw materials:

N-<3-Hydroxy-but-2-enyliden>-2-aethylsulfamoyl-5-chlor-4-sulfamoyl-anilin

N-<3-Hydroxy-3-phenyl-propenyliden>-2-aethylsulfamoyl-5-chlor-4-sulfamoyl-anilin

6-Chlor-7-sulfamoyl-2-ethyl-3-carboxy-3.4-dihydro-2H-1.2.4-benzothiadiazin-1.1-dioxid