2-AMINO-4,6-DI-TERT-BUTYLPHENOL

Base Information

• Chemical Name: 2-AMINO-4,6-DI-TERT-BUTYLPHENOL
• CAS No.: 1643-39-6
• Molecular Formula: C14H23NO
• Molecular Weight: 221.343
• Hs Code.: 2922299090
• Mol file: 1643-39-6.mol

Synonyms:4,6-di-tert-butyl-1-phenol-2-amine;4,6-di-(tert-butyl)-2-aminophenol;2,4-di-tert-butyl-6-aminophenol;2-amino-4,6-bis(1,1-dimethylethyl)phenol;2-amino-4,6-di-tert-butylphenol;

Chemical Property of 2-AMINO-4,6-DI-TERT-BUTYLPHENOL

Chemical Property:

• Melting Point: 171-172 °C
• Boiling Point: 297.9±40.0 °C(Predicted)
• PKA: 11.36±0.23(Predicted)
• PSA: 46.25000
• Density: 0.990±0.06 g/cm3(Predicted)
• LogP: 4.15060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-4,6-di-tert-butylphenol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-4,6-DI-TERT-BUTYLPHENOL

There total 18 articles about 2-AMINO-4,6-DI-TERT-BUTYLPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3,5-di-tert-butyl-o-benzoquinone (3383-21-9) → 2-amino-4,6-di-tertbutylphenol (1643-39-6)

Guidance literature:

3,5-di-tert-butyl-o-benzoquinone; With ammonium hydroxide; In methanol; at 20 ℃; for 0.166667h;

With sodium tetrahydroborate;

DOI:10.1016/S0960-894X(03)00041-6

Reference yield: 84.0%

2,4-di-tert-butyl-6-nitrophenol (20039-94-5) → 2-amino-4,6-di-tertbutylphenol (1643-39-6)

Guidance literature:

With 1% Pd/C; hydrogen; In methanol;

DOI:10.1002/ejic.200701339

Reference yield: 65.0%

dl-alanylglycine (1188-01-8) + 3,5-di-tert-butyl-o-benzoquinone (3383-21-9) → pyruvoylglycine (3997-91-9) + 2-amino-4,6-di-tertbutylphenol (1643-39-6)

Guidance literature:

In ethanol; water; at 50 ℃; for 5h;

upstream raw materials:

2,4-di-tert-Butylphenol

4-azido-2,4,6-tri-t-butyl-2,5-cyclohexadien-1-one

3,5-di-tert-butyl-1,2-benzoquinone 1-oxime

2,4-di-tert-butyl-6-nitrophenol

Downstream raw materials:

2,4-di-tert-butyl-6-<(o-hydroxy-α-methylbenzylidene)amino>phenol

2,4-di-tert-butyl-6-{[(2-hydroxyphenyl)methylene]amino}phenol

C₂₈H₄₂N₂O₂

1,2-bis(3,5-di-tert-butyl-2-hydroxyphenyl)oxamide

Refernces

• 1、 Vol'eva, V. B.,Prokof'eva, T. I.,Prokof'ev, A. I.,Belostotskaya, I. S.,Komissarova, N. L.,Ershov, V. V.. "Reactions of isomeric 3,6- and 3,5-di-tert-butyl-ortho-benzoquinones". . p. 1720 - 1724. Retrieved 1995.
• 2、 -. "Tridentate [ONO] tungsten coordination compound and optical application thereof". . . Retrieved 2021/05/29.
• 3、 Dong, Kui,Jin, Xiao-Ling,Chen, Shihao,Wu, Li-Zhu,Liu, Qiang. "Controllable synthesis of 2- And 3-aryl-benzomorpholines from 2-aminophenols and 4-vinylphenols". supporting information. p. 7941 - 7944. Retrieved 2020/08/14.