10355-06-3

Basic information

• Product Name: Benzene, 1-methyl-3-(methylsulfonyl)-
• CAS NO: 10355-06-3
• Molecular Formula: C8H10O2S
• Molecular Weight: 170.232
• Mol File: 10355-06-3.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methyl-3-(methylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methyl-3-(methylsulfonyl)-(10355-06-3)
• EPA Substance Registry System: Benzene, 1-methyl-3-(methylsulfonyl)-(10355-06-3)

Safety Data

• Hazardous Substances Data: 10355-06-3(Hazardous Substances Data)

Usage

Description

Benzene, 1-methyl-3-(methylsulfonyl)-, also known as a toluene derivative, is an organic chemical compound characterized by the molecular formula C8H10O2S. It features a benzene ring with a methyl group and a methylsulfonyl group attached, classifying it as a sulfone. Benzene, 1-methyl-3-(methylsulfonyl)is recognized for its aromatic properties and is utilized in various industrial applications, including as a solvent and in the synthesis of pharmaceuticals and dyes. However, due to its potential harmful effects when inhaled and its irritating nature upon contact with skin and eyes, it requires careful handling.

Uses

Used in Chemical Synthesis:
Benzene, 1-methyl-3-(methylsulfonyl)-, is employed as a key intermediate in the synthesis of various organic compounds, particularly in the production of pharmaceuticals and dyes. Its unique structure allows for versatile chemical reactions, making it a valuable component in the creation of a wide range of chemical products.
Used in Solvent Applications:
Benzene, 1-methyl-3-(methylsulfonyl)serves as a solvent in certain industrial processes due to its ability to dissolve other substances. Its solubility properties are beneficial in various chemical reactions and manufacturing procedures, facilitating the production of different types of products.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, Benzene, 1-methyl-3-(methylsulfonyl)-, is utilized in the development and manufacturing of specific drugs. Its chemical properties make it suitable for use in medicinal chemistry, contributing to the formulation of new therapeutic agents.
Used in Dye Production:
Benzene, 1-methyl-3-(methylsulfonyl)also finds application in the dye industry, where it is used in the production of various types of dyes. Its aromatic and sulfone characteristics enable it to contribute to the color and stability of the dyes produced.

Upstream product

• 4886-77-5 3-methylthioanisole 
• 1899-93-0 3-methylphenylsulfonyl chloride 
• 74-88-4 methyl iodide 
• 108-88-3 toluene 
• 7143-01-3 Methanesulfonic anhydride 
• 625-95-6 3-Iodotoluene 
• 67-68-5 dimethyl sulfoxide 
• 591-17-3 meta-bromotoluene 
• 17933-03-8 m-tolylboronic acid 
• 616-38-6 carbonic acid dimethyl ester 
• 55510-25-3 3-methylbenzene-1-sulfonohydrazide 
• 868-85-9 Dimethyl phosphite 
• 2386-57-4 methanesulfonic acid sodium salt 
• 20277-69-4 sodium methansulfinate 

Downstream Products

• 923001-98-3 1-(3-methylphenylsulfonyl)-5-hexen-2-one 
• 851785-28-9 methyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate 
• 253342-48-2 4,4,5,5-tetramethyl-2-m-tolyl-1,3,2-dioxaborolane 
• 1206713-03-2 [6-bromo-7-(3-methanesulphonylbenzyloxy)quinazolin-4-yl](isopropyl)amine 
• 923001-90-5 (1R,5R)-1-(3-methylphenylsulfonyl)bicyclo[3.1.0]hexan-2-one 
• 923001-82-5 1-diazo-1-(3-methylphenylsulfonyl)-5-hexen-2-one 
• 5345-27-7 3-(methylsulfonyl)benzoic acid 
• 1206713-19-0 (E/Z)-N'-[2-cyano-5-(3-methanesulphonylbenzyloxy)-4-bromophenyl]-N,N-dimethylformamidine 
• 82657-76-9 1-(bromomethyl)-3-(methylsulfonyl)benzene 

Relevant articles and documents

Indium-catalysed aryl and alkyl sulfonylation of aromatics

Commercially available indium (III) triflate is shown to be an extremely efficient catalyst for the sulfonylation of both activated and deactivated aromatics.

Bismuth(III) trifluoromethanesulfonate: An efficient catalyst for the sulfonylation of arenes

-

Friedel-Crafts sulfonylation of aromatics catalysed by solid acids: An eco-friendly route for sulfone synthesis

A mild and efficient catalytic method for Friedel-Crafts sulfonylation of arenes to the corresponding sulfones using a catalytic amount of reusable solid acid and arene- or alkanesulfonyl chlorides, sulfonic anhydrides and sulfonic acids as sulfonylating agents is described. Solid acids enable formation of a sulfone by the reaction of a sulfonic acid and an arene for the first time. In pursuit of the development of the best catalytic system, various metal-exchanged K10 montmorillonites and synthetic zeolites such as zeolite beta, zeolite Y and ZSM-5 have been screened for Friedel-Crafts sulfone synthesis. Fe3+-montmorillonite in the family of clays and zeolite beta in the family of zeolites exhibit higher activity. The activity is correlated to the presence of the right mix of Bronsted and Lewis acidic sites. The regioselective sulfonylation of toluene and naphthalene are studied in which para and beta selectivities are observed respectively. The Royal Society of Chemistry 2000.

Synergistic cooperative effect of CF3SO2Na and bis(2-butoxyethyl)ether towards selective oxygenation of sulfides with molecular oxygen under visible-light irradiation

A safe, practical and eco-friendly method for the switchable synthesis of sulfoxides and sulfones through visible-light-initiated oxygenation of sulfides at ambient temperature under transition-metal-, additives-free and minimal solvent conditions. The synergistic catalytic efforts between CF3SO2Na and 2-butoxyethyl ether represents the key promoting factor for the reaction. This journal is

Lifitegrast intermediate and preparation method thereof

The invention relates to the field of pharmaceutical and chemical production, and discloses a lifitegrast intermediate and a preparation method thereof. A reaction route of the preparation method is as described in the specification. The preparation metho