104530-80-5 Usage
Description
3-Furanamine, tetrahydro-, (3S)-, 4-methylbenzenesulfonate, also known as (S)-3-Aminotetrahydrofuran tosylate, is an organic compound with a complex chemical structure. It is characterized by its furanamine core, which is a tetrahydrofuran ring with an amine group attached to it. The compound is further modified by a 4-methylbenzenesulfonate group, which is derived from toluene. This unique structure endows it with specific reactivity and potential applications in various chemical and pharmaceutical processes.
Uses
Used in Pharmaceutical Industry:
3-Furanamine, tetrahydro-, (3S)-, 4-methylbenzenesulfonate is used as a reagent for the synthesis of complex organic molecules, particularly in the pharmaceutical industry. Its unique structure allows it to participate in various chemical reactions, making it a valuable building block for the development of new drugs.
Used in the Synthesis of κ-Opioid Receptor Antagonists:
In the field of medicinal chemistry, 3-Furanamine, tetrahydro-, (3S)-, 4-methylbenzenesulfonate is used as a reagent in the synthesis of oxadiazolyl-quinolinyl-N-(pyranyl)piperidinamines. These compounds have potential as κ-opioid receptor (KOR) antagonists, which are being investigated for their therapeutic potential in treating various conditions, such as pain, addiction, and mood disorders.
Used in the Preparation of N-(4-Fluoro-3-Methyl-Phenyl)-3-[[(3S)-Tetrahydrofuran-3-Yl]-Sulfamoyl]Benzamide Derivatives:
Another application of 3-Furanamine, tetrahydro-, (3S)-, 4-methylbenzenesulfonate is in the preparation of N-(4-fluoro-3-methyl-phenyl)-3-[[(3S)-tetrahydrofuran-3-yl]-sulfamoyl]benzamide derivatives. These compounds may have potential applications in various therapeutic areas, including the treatment of inflammatory diseases, autoimmune disorders, and certain types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 104530-80-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,5,3 and 0 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 104530-80:
(8*1)+(7*0)+(6*4)+(5*5)+(4*3)+(3*0)+(2*8)+(1*0)=85
85 % 10 = 5
So 104530-80-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H8O3S.C4H9NO/c1-6-2-4-7(5-3-6)11(8,9)10;5-4-1-2-6-3-4/h2-5H,1H3,(H,8,9,10);4H,1-3,5H2/t;4-/m.1/s1
104530-80-5Relevant articles and documents
Diacylglycerol acyltransferase inhibitors
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Page/Page column 20, (2010/11/27)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
Application of N-Tritylmethionine in the Preparation of Heterocycles of Biological and Synthetic Interest
Barlos, Kleomenis,Papaioannou, Dionysios,Voliotis, Stavros
, p. 1127 - 1134 (2007/10/02)
Treatment of the methylsulfonium salts of the corresponding N-tritylmethionine derivatives with sodium hydride or potassium tert-butoxide provides the heterocycles N-trityl-L-homoserine lactone (3), (S)- and (R)-3-(N-tritylamino)tetrahydrofuran (7a, 7b), (S)-1-hydroxy-3-(N-tritylamino)-2-pyrrolidinone (14), (S)-4-(N-tritylamino)-1,2-oxazinan-3-one (15), (S)-3-(N-tritylamino)-2-pyrrolidone (23), (S)-1-tert-butyloxycarbonylamino-3-(N-tritylamino)-2-pyrrolidone (27), and (S)-2-methyl-4-(N-tritylamino)-1,2-oxazinan-3-one (18).Methylation of 14 and 15 yields (S)-1-methoxy-3-(N-tritylamino)-2-pyrrolidone (17) and 18, respectively.The stereochemistry of compounds 3, 7a, and 17 has been determined by X-ray crystal structure analysis.
