1046427-59-1

Basic information

• Product Name: methyl (RS)-5-tris(phenylthio)methylcyclopent-1-enecarboxylate
• Synonyms: methyl (RS)-5-tris(phenylthio)methylcyclopent-1-enecarboxylate
• CAS NO: 1046427-59-1
• Molecular Weight: 464.673
• Mol File: 1046427-59-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (RS)-5-tris(phenylthio)methylcyclopent-1-enecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (RS)-5-tris(phenylthio)methylcyclopent-1-enecarboxylate(1046427-59-1)
• EPA Substance Registry System: methyl (RS)-5-tris(phenylthio)methylcyclopent-1-enecarboxylate(1046427-59-1)

Safety Data

• Hazardous Substances Data: 1046427-59-1(Hazardous Substances Data)

Upstream product

• 4832-52-4 tris(phenylthio)methane 
• 438045-06-8 5-acetoxycyclopent-1-enecarboxylic acid methyl ester 

Downstream Products

• 1046427-88-6 methyl (1R,2S,5S,αS)-2-[N-benzyl-N-(α-methylbenzyl)amino]-5-tris(phenylthio)methylcyclopentanecarboxylate 
• 1046427-91-1 methyl (1S,2R,5R,αR)-2-[N-(3,4-dimethoxybenzyl)-N-(α-methylbenzyl)amino]-5-tris(phenylthio)methylcyclopentanecarboxylate 

Relevant articles and documents

Parallel kinetic resolution of methyl (RS)-5-tris(phenylthio)methyl-cyclopent-1-ene-carboxylate for the asymmetric synthesis of (1R,2S,5S)- and (1S,2R,5R)-5-methyl-cispentacin

Parallel kinetic resolution of methyl (RS)-5-tris(phenylthio)methyl-cyclopent-1-ene-carboxylate with a 50:50 pseudoenantiomeric mixture of lithium (S)-N-benzyl-N-(α-methylbenzyl)amide and lithium (R)-N-3,4-dimethoxybenzyl-N-(α-methylbenzyl)amide provides an efficient entry to the corresponding homochiral methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tris(phenylthio)methyl-cyclopentane-carboxylate derivatives in >98% de, with subsequent, sequential desulfurisation with Raney Nickel, N-debenzylation and ester hydrolysis furnishing (1R,2S,5S)- and (1S,2R,5R)-5-methyl-cispentacin in high yield, >98% de and >98% ee.