1096880-75-9 Usage
Description
5-Fluoro-2-morpholinobenzoic Acid is a chemical compound with the molecular formula C11H11FNO4, belonging to the benzoic acid derivatives. It features a fluorine atom and a morpholino group, which endows it with the capability to form hydrogen bonds. This versatile chemical has been the subject of research for its potential pharmacological properties, such as its ability to act as a relaxant for smooth muscle tissue, its anti-inflammatory effects, and its potential as a drug candidate for treating autoimmune diseases. Furthermore, it plays a role in the synthesis of other pharmaceutical compounds, highlighting its significance in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
5-Fluoro-2-morpholinobenzoic Acid is used as a pharmacological agent for its potential to act as a relaxant for smooth muscle tissue, providing a basis for its use in conditions involving muscle tension or spasms.
5-Fluoro-2-morpholinobenzoic Acid is used as an anti-inflammatory agent, leveraging its properties to potentially alleviate inflammation in various medical conditions.
5-Fluoro-2-morpholinobenzoic Acid is utilized as a potential drug candidate for treating autoimmune diseases, due to its pharmacological profile that may help modulate immune responses.
Additionally, 5-Fluoro-2-morpholinobenzoic Acid is used as a synthetic intermediate in the development and production of other pharmaceutical compounds, contributing to the creation of novel medications and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 1096880-75-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,6,8,8 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1096880-75:
(9*1)+(8*0)+(7*9)+(6*6)+(5*8)+(4*8)+(3*0)+(2*7)+(1*5)=199
199 % 10 = 9
So 1096880-75-9 is a valid CAS Registry Number.
1096880-75-9Relevant articles and documents
Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities
Zhu, Huajian,Li, Wenlong,Shuai, Wen,Liu, Yang,Yang, Limei,Tan, Yuchen,Zheng, Tiandong,Yao, Hong,Xu, Jinyi,Zhu, Zheying,Yang, Dong-Hua,Chen, Zhe-Sheng,Xu, Shengtao
, (2021/03/08)
A series of novel N-benzylbenzamide derivatives were designed and synthesized as tubulin polymerization inhibitors. Among fifty-one target compounds, compound 20b exhibited significant antiproliferative activities with IC50 values ranging from 12 to 27 nM against several cancer cell lines, and possessed good plasma stability and satisfactory physicochemical properties. Mechanism studies demonstrated that 20b bound to the colchicine binding site and displayed potent anti-vascular activity. Notably, the corresponding disodium phosphate 20b-P exhibited an excellent safety profile with the LD50 value of 599.7 mg/kg (i.v. injection), meanwhile, it significantly inhibited tumor growth and decreased microvessel density in liver cancer cell H22 allograft mouse model without obvious toxicity. Collectively, 20b and 20b-P are novel promising anti-tubulin agents with more druggable properties and deserve to be further investigated for cancer therapy.
