1110772-05-8Relevant articles and documents
Preparation method of (1R,3S)-3-aminocyclopentanol and intermediate thereof
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, (2020/05/05)
The invention discloses a preparation method of (1R,3S)-3-aminocyclopentanol and an intermediate thereof. The invention provides a preparation method of a compound as shown in a formula I'-1. The preparation method comprises a step: re-crystallizing a mixture of compounds as shown in the formula I'-1 and the formula I'-2 in a solvent, wherein the solvent is a mixed solvent of a poor solvent and agood solvent, the poor solvent is a ketone solvent and methanol, and the good solvent is water. The preparation method is high in reaction yield, and a single-configuration product with high optical purity can be obtained.
Preparation of optically-pure cyclic amino alcohol and salt thereof
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Paragraph 0093-0104, (2020/01/12)
The invention relates to the field of chemical pharmacy, in particular to a method for preparing an optically-pure cyclic amino alcohol and a salt thereof. The method comprises: 1) catalytic hydrogenation: a compound (12) is subjected to catalytic hydroge
A (1 R, 3 S) -3 - amino-cyclopentanol hydrochloride preparation method (by machine translation)
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Paragraph 0034; 0038, (2019/05/08)
The invention discloses a (1 R, 3 S) - 3 - amino-cyclopentanol hydrochloride of the preparation method, the method using chiral carboxylic acid with hydroxylamine to form the amide as chiral source, in copper catalyzed oxidation in the reaction system to rapidly obtain a chiral Diels - alder reaction product, after passes through the reduction reaction and alkaline deprotection reaction, and acidified after reaction to obtain the target product. Chiral inducing reagent chiral carboxylic acid by simple acidification, extraction processing can be reclaimed and reused. This kind of (1 R, 3 S) - 3 - amino-cyclopentanol hydrochloride preparation method has high operation safety and high selectivity, raw materials are easy, and the cost is low, the reaction time is short and simple process flow and the like. (by machine translation)