112652-46-7

Basic information

• Product Name: Fragransin A2
• Synonyms: Fragransin A2;(+)-Fragransin A;4,4'-[(2R,3R,4R,5R)-Tetrahydro-3,4-dimethyl-2,5-furandiyl]bis[2-methoxyphenol]
• CAS NO: 112652-46-7
• Molecular Formula: C₂₀H₂₄O₅
• Molecular Weight: 344.40156
• Mol File: 112652-46-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 198-200 °C
• Boiling Point: 509.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.175±0.06 g/cm3(Predicted)
• PKA: 9.61±0.35(Predicted)
• CAS DataBase Reference: Fragransin A2(CAS DataBase Reference)
• NIST Chemistry Reference: Fragransin A2(112652-46-7)
• EPA Substance Registry System: Fragransin A2(112652-46-7)

Safety Data

• Hazardous Substances Data: 112652-46-7(Hazardous Substances Data)

Usage

Description

Fragransin A2 is a naturally occurring compound isolated from the marine bacterium Microbulbifer sp., characterized by a unique linear peptide structure comprising 14 amino acids with several unusual modifications. This distinctive molecular composition endows Fragransin A2 with intriguing pharmaceutical and agricultural potential, particularly due to its potent antifungal and antibacterial properties.

Uses

Used in Pharmaceutical Industry:
Fragransin A2 is used as an antimicrobial agent for its potent antifungal and antibacterial activities. It serves as a promising candidate for the development of new antimicrobial drugs to combat resistant infections and emerging pathogens.
Used in Agricultural Industry:
Fragransin A2 is used as a biocontrol agent to protect plants against pathogenic fungi. Its natural origin and bioactivity make it a suitable alternative to conventional chemical fungicides, offering an eco-friendly and sustainable approach to managing plant diseases and promoting crop health.

Upstream product

• 915158-87-1 C₂₇H₃₀O₅ 
• 1536264-02-4 C₃₆H₄₀O₁₁S₂ 
• 1536263-72-5 (7R,7′R,8S,8′S)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol 
• 935431-19-9 C₃₀H₃₄O₅ 
• 935431-23-5 (2R,3R,4R)-4-(4-allyloxy-3-methoxyphenyl)-1-(4-benzyloxy-3-methoxyphenyl)-4-(tert-butyldimethylsilanyloxy)-2,3-dimethylbutan-1-ol 
• 935431-18-8 (1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol 
• 915158-62-2 (2R,3R,4R)-4-(4-allyloxy-3-methoxyphenyl)-4-(tert-butyldimethylsilanyloxy)-2,3-dimethylbutyraldehyde 
• 149777-72-0 4-Bromo-2-methoxy-1-<(tert-butyldimethylsilyl)oxy>benzene 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 954114-85-3 (4R,5S)-5-(4-(benzyloxy)-3-methoxyphenyl)-4-methyldihydrofuran-2(3H)-one 
• 954114-84-2 C₂₅H₃₅O₃SiN 
• 954114-83-1 (2R,3S)-3-(4-(benzyloxy)-3-methoxyphenyl)-3-((tert-butyldimethylsilyl)oxy)-2-methylpropan-1-ol 
• 954114-82-0 C₃₀H₄₃NO₆Si 
• 954114-81-9 C₂₄H₂₉NO₆ 

Downstream Products

• 61949-24-4 (+)-galbelgin 
• 1204656-82-5 C₄₂H₄₈O₁₁ 
• 528-63-2 galbelgin 
• 10569-12-7 (-)-Galbelgin 
• 528-63-2 galgravin 
• 528-63-2 veraguensin 
• 3569-00-4 (+/-)-trans-4-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-2,3-dimethylnaphthalene 
• 5701-82-6 1,4-bis(3,4-dimethoxyphenyl)-2,3-dimethylbutane 
• 91377-15-0 malabaricanol diacetate 

Relevant articles and documents

Synthesis of all stereoisomers of 3,3′-dimethoxy-7,7′- epoxylignane-4,4′-diol and their plant growth inhibitory activity

All stereoisomers of 3,3′-dimethoxy-7,7′-epoxylignane-4, 4′-diol were synthesized to examine the effect of stereochemistry on their plant growth inhibitory activity using lettuce and Italian ryegrass. The effect of structural modifications such as dehydro

Glycosides from the bark of Machilus robusta

Six new glycosidic constituents (1-6), together with 10 known analogs, have been isolated from the bark of Machilus robusta. Structures of the new compounds, including the absolute configurations, were determined by spectroscopic and chemical methods as (

Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations

We have shown that manassantin A downregulated the HIF-1α expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin