112830-95-2 Usage
Description
HU-210, also known as T293200, is a synthetic agonist analog of Δ9-Tetrahydrocannabinol (THC), the primary psychoactive component of marijuana. It is a potent central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist, binding to neuroblastoma cell membrane CB1 receptors with similar affinity as CP-55940. HU-210 is a liquid and is regulated as a Schedule I compound in the United States, with its exempt preparation intended for research and forensic applications.
Uses
Used in Pharmaceutical Research:
HU-210 is used as a research compound for studying the effects and mechanisms of action of cannabinoids on the central and peripheral cannabinoid receptors. Its potent agonist properties make it a valuable tool in understanding the therapeutic potential of cannabinoids in various medical conditions.
Used in Forensic Applications:
HU-210 is used as an analytical reference standard in forensic analysis to identify and quantify the presence of synthetic cannabinoids in biological samples, such as blood, urine, or tissue. This helps in the investigation of drug-related crimes and the assessment of drug abuse patterns.
Used in Drug Development:
HU-210 serves as a starting point for the development of new drugs with improved safety, efficacy, and pharmacokinetic profiles. By studying its interactions with cannabinoid receptors, researchers can design novel compounds with targeted therapeutic effects and reduced side effects.
Used in Toxicological Studies:
HU-210 is used in toxicological research to evaluate the safety and potential risks associated with synthetic cannabinoids. This helps in understanding the toxic effects of these compounds and establishing safety guidelines for their use in medical and recreational settings.
Biological Activity
A highly potent cannabinoid receptor agonist (K i values are 0.061 and 0.52 nM at cloned human CB 1 and CB 2 receptors respectively). Induces spatial memory deficits and suppresses hippocampal firing rates in rats. Also displays agonist activity at GPR55 (EC 50 = 26 nM). Also available as part of the Cannabinoid Receptor Agonist Tocriset? .
Check Digit Verification of cas no
The CAS Registry Mumber 112830-95-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,8,3 and 0 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 112830-95:
(8*1)+(7*1)+(6*2)+(5*8)+(4*3)+(3*0)+(2*9)+(1*5)=102
102 % 10 = 2
So 112830-95-2 is a valid CAS Registry Number.
InChI:InChI=1/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h13-15,19-20,26-27H,6-12,16H2,1-5H3/t19-,20-/m0/s1
112830-95-2Relevant articles and documents
SYNTHESIS OF THE INDIVIDUAL, PHARMACOLOGICALLY DISTINCT, ENANTIOMERS OF A TETRAHYDROCANNABINOL DERIVATIVE
Mechoulam, Raphael,Lander, Naftali,Breuer, Aviva,Zahalka, Jamal
, p. 315 - 318 (2007/10/02)
The individual enantiomers of the 1,1-dimethylheptyl homolog of 7-hydroxy-Δ6-tetrahydrocannabinol, (1) and (2a), which exhibit distinct pharmacological profiles, have been obtained with very high e.e. by synthesis from the antipodes of myrtenol.