113512-71-3

Basic information

• Product Name: 5-AMINO-2,4-DIFLUOROPHENOL
• Synonyms: 5-AMINO-2,4-DIFLUOROBENZENOL;5-AMINO-2,4-DIFLUOROPHENOL;2,4-Difluoro-5-hydroxyaniline
• CAS NO: 113512-71-3
• Molecular Formula: C₆H₅F₂NO
• Molecular Weight: 145.11
• Mol File: 113512-71-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 189-190°C
• Boiling Point: 246.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.472±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.79±0.23(Predicted)
• CAS DataBase Reference: 5-AMINO-2,4-DIFLUOROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2,4-DIFLUOROPHENOL(113512-71-3)
• EPA Substance Registry System: 5-AMINO-2,4-DIFLUOROPHENOL(113512-71-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 113512-71-3(Hazardous Substances Data)

Usage

General Description

5-Amino-2,4-difluorophenol is a chemical compound that consists of a phenol ring with amino and difluoromethyl substituents. It is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 5-AMINO-2,4-DIFLUOROPHENOL has been studied for its potential as a corrosion inhibitor for metals and as a component in the development of dyes and pigments. It is important to handle this chemical with care, as it may cause irritation to the skin, eyes, and respiratory system upon exposure. Additionally, it may be harmful if ingested or inhaled, and proper protective measures should be taken when working with this compound.

Upstream product

• 152169-43-2 2,4-difluorophenyl ethyl carbonate 
• 367-27-1 2,4-difluorophenol 
• 113512-57-5 2,4-difluoro-5-nitrophenol 

Downstream Products

• 956488-66-7 4-(5-amino-2,4-difluorophenoxy)-3-nitropyridin-2-amine 
• 152835-84-2 ethyl 3,5-difluoro-6-pivaloylamino-2-(2-tetrahydropyranyloxy)-4-trimethylsilylbenzoate 
• 152169-46-5 2,4-difluoro-5-pivaloylamino-3-trimethylsilyl-O-(2-tetrahydropyranyl)phenol 
• 152835-78-4 ethyl 3,5-difluoro-6-(N-pivaloylamino)-2-(2-tetrahydropyranyloxy)benzoate 
• 152169-45-4 2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol 
• 152835-71-7 6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one 
• 152169-56-7 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-4H-1-benzopyran-4-one 

Relevant articles and documents

2-OXO-THIAZOLE DERIVATIVES AS A2A INHIBITORS AND COMPOUNDS FOR USE IN THE TREATMENT OF CANCERS

The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. The invention further relates to the use of the compounds of Formula (I) as A2A inhibitors. The invention also relates to the use of the compounds of Formula (I) for the treatment and/or prevention of cancer. The invention also relates to a process for manufacturing compounds of Formula (I).

KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES

The present invention is concerned with novel compounds useful in the treatment of hyperproliferative diseases and mammalian cancers, especially human cancers. The invention also pertains to methods of modulating kinase activities, pharmaceutical compositions, and methods of treating individuals, incorporating or using the compounds. The preferred compounds are active small molecules set forth in formulae Ia-Iww.

Synthesis of an ethyl 6-amino-3,5-difluorosalicylate derivative by sequential regioselective directed ortho- metalation; a practical synthesis of 4',5-Diamino-3',6,8-trifluoroflavone, a potent antitumor agent

The multigram scale synthesis of 4',5-diamino-3'6,8-trifluoroflavone, a potent antitumor agent, is described in which regioselective introduction of a carbonyl group into the ortho-position to the amide group of 2-[2,4-difluoro-5-(pivaloylamino)phenyoxy]tetrahydropyran is achieved by using sequential direct ortho-metalations as the key step.