113900-75-7 Usage
Description
KouMine N-oxide, an alkaloid derived from the plant Gelsemium elegans, is a naturally occurring chemical compound with a history of traditional use in herbal medicine. It is known for its potential analgesic and sedative properties, and recent studies have highlighted its pharmacological effects, such as acting as a partial agonist at the glycine receptor and exhibiting neuroprotective properties. Moreover, research indicates that KouMine N-oxide may also possess anti-cancer capabilities by inducing apoptosis in cancer cells. Further investigation is required to fully explore and understand the medical applications of this compound.
Uses
Used in Pharmaceutical Industry:
KouMine N-oxide is used as a potential analgesic and sedative agent for its traditional applications in herbal medicine, aiming to provide relief from pain and promote relaxation.
Used in Neuropharmacology Research:
KouMine N-oxide is used as a research compound for its potential as a partial agonist at the glycine receptor, which may contribute to its neuroprotective properties and could be beneficial in the study and treatment of neurological disorders.
Used in Oncology Research:
KouMine N-oxide is used as a potential anti-cancer agent for its ability to induce apoptosis in cancer cells, offering a novel avenue for cancer treatment that requires further exploration and development.
Check Digit Verification of cas no
The CAS Registry Mumber 113900-75-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,9,0 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 113900-75:
(8*1)+(7*1)+(6*3)+(5*9)+(4*0)+(3*0)+(2*7)+(1*5)=97
97 % 10 = 7
So 113900-75-7 is a valid CAS Registry Number.
113900-75-7Relevant articles and documents
STUDIES ON THE INDOLE ALKALOIDS OF GELSEMIUM ELEGANS (THAILAND): STRUCTURE ELUCIDATION AND PROPOSAL OF BIOGENETIC ROUTE
Ponglux, Dhavadee,Wongseripipatana, Sumphan,Subhadhirasakul, Sanan,Takayama, Hiromitsu,Yokota, Masaki,et al.
, p. 5075 - 5094 (2007/10/02)
Chemical investigation of the roots of Gelsemium elegans collected in Thailand resulted in the isolation of the new indole alkaloids, 16-epi-voacarpine, 19-hydroxydihydrogelsevirine, and 19-(Z)-taberpsychine, along with eight known bases.Among them, the structure of "akuammidine" and koumidine were revised to have 19-(Z) ethylidene configuration.From the seeds of G. elegans 14-hydroxygelsedine was obtained.Furthermore, three new alkaloids, koumine N-oxide, gelsemine N-oxide, and 19-oxo-gelsenicine, were found from the leaves of G. elegans.A new and plausible biogenetic route of gelsemium alkaloids is proposed.
