119169-84-5

Basic information

• Product Name: 3-Bromo-N-(1,1-dimethylethyl)androsta-3,5-diene-17β-carboxamide
• Synonyms: 3-Bromo-N-(1,1-dimethylethyl)androsta-3,5-diene-17β-carboxamide
• CAS NO: 119169-84-5
• Molecular Weight: 434.46
• Mol File: 119169-84-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Bromo-N-(1,1-dimethylethyl)androsta-3,5-diene-17β-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-N-(1,1-dimethylethyl)androsta-3,5-diene-17β-carboxamide(119169-84-5)
• EPA Substance Registry System: 3-Bromo-N-(1,1-dimethylethyl)androsta-3,5-diene-17β-carboxamide(119169-84-5)

Safety Data

• Hazardous Substances Data: 119169-84-5(Hazardous Substances Data)

Upstream product

• 302-97-6 androst-4-en-3-one-17β-carboxylic acid 
• 75-64-9 tert-butylamine 

Downstream Products

• 119169-78-7 epristeride 

Relevant articles and documents

Vinyl fluoride as a mimic of the 'intermediate' enol form in the 5α-reductase transformation: Synthesis and in vitro activity of (N-1′,1′-dimethylethyl)-3-haloandrost-3,5-diene-17β- carboxamides

(N-1′,1′-Dimethylethyl)-3-haloandrost-3,5-diene-17ss- carboxamides (9-11) and the methyl ester 8 were prepared from 3-chloro/bromoandrost-3,5-diene-17β-carboxylic chloride/bromide (6/7), which were obtained from pregnenolone. In comparison with finasteride and 4-MA, compounds 8-11 showed very weak inhibitory activity (≤10% inhibition) on human type I 5 α-reductase (transfected 293 cells) at 100 and 1000 nM concentrations. Against the type II enzyme, chloro compounds 8 and 9, and bromo 10 had no effect at 100 nM concentration, however, they were weak inhibitors of the type II (6.0% 50 = 480 nM) was observed with the 3-vinyl fluoride analogue 11.