121961-98-6

Basic information

• Product Name: 1-Acenaphthylenol, 1,2-dihydro-, (1S)-
• Synonyms: 1-Acenaphthylenol, 1,2-dihydro-, (1S)-;(S)-1,2-Dihydroacenaphthylen-1-ol
• CAS NO: 121961-98-6
• Molecular Formula: C₁₂H₁₀O
• Molecular Weight: 170.2072
• Mol File: 121961-98-6.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Acenaphthylenol, 1,2-dihydro-, (1S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acenaphthylenol, 1,2-dihydro-, (1S)-(121961-98-6)
• EPA Substance Registry System: 1-Acenaphthylenol, 1,2-dihydro-, (1S)-(121961-98-6)

Safety Data

• Hazardous Substances Data: 121961-98-6(Hazardous Substances Data)

Usage

Synthesis of pharmaceuticals

Used as a starting material or intermediate in the production of various pharmaceuticals.

Synthesis of agrochemicals

Utilized in the creation of chemicals for agricultural purposes, such as pesticides and fertilizers.

Synthesis of other organic compounds

Serves as a building block for the synthesis of various organic compounds.

Upstream product

• 2235-15-6 1(2H)-acenaphthylenone 
• 6306-07-6 1-acenaphthenol 
• 83-32-9 acenaphthene 
• 876-27-7 4-chlorophenyl acetate 
• 76-86-8 Triphenylsilyl chloride 
• 108-22-5 Isopropenyl acetate 
• 164665-41-2 Carbonic acid acenaphthen-1-yl ester methyl ester 
• 108-21-4 Isopropyl acetate 
• 208-96-8 acenaphthylene 
• 14966-36-0 (R)-(+)-1,2-dihydroacenaphthylen-1-yl acetate 
• 14966-36-0 1-acetoxyacenaphthene 
• 121926-58-7 1-acenaphthenyl camphanate 

Downstream Products

• 228246-75-1 (R)-1-(acenaphthen-1-yl)-piperidine-4-one 
• 228246-77-3 (R)-4-phenylamino-1-(acenaphthen-1-yl)-piperidine4-carbonitrile 
• 228246-78-4 (S)-4-phenylamino-1-(acenaphthen-1-yl)-piperidine-4-carbonitrile 
• 228246-76-2 (S)-1-(acenaphthen-1-yl)-piperidine-4-one 
• 228246-74-0 (S)-1-Acenaphthylamine 

Relevant articles and documents

Silylative Kinetic Resolution of Racemic 1-Indanol Derivatives Catalyzed by Chiral Guanidine

Efficient kinetic resolution of racemic 1-indanol derivatives was achieved using triphenylchlorosilane by asymmetric silylation in the presence of chiral guanidine catalysts. The chiral guanidine catalyst (R,R)-N-(1-(β-naphthyl)ethyl)benzoguanidine was found to be highly efficient as only 0.5 mol % catalyst loading was sufficient to catalyze the reaction of various substrates with appropriate conversion and high s-values (up to 89). This catalyst system was successfully applied to the gram-scale silylative kinetic resolution of racemic 1-indanol with high selectivity.

1-acenaphthenol synthesis and enantiomer separation method

The invention discloses a 1-acenaphthenol synthesis and enantiomer separation method. The method particularly comprises the following steps that 1-acenaphthenone serves as a raw material, catalytic reduction hydrogenation can be conducted through a catalyst to obtain racemic 1-acenaphthenol, the racemic 1-acenaphthenol is subjected to dynamic kinetic splitting and then separated to obtain an R-1-acenaphthenol acyl compound and S-1-acenaphthenol, the 1-acenaphthenol is subjected to dynamic kinetic splitting, only an R-1-acenaphthenol acyl compound is obtained, the R-1-acenaphthenol acyl compound obtained through kinetic splitting or dynamic kinetic splitting is hydrolyzed, and then R-1-acenaphthenol can be obtained. The method has the advantages of being easy to implement, high in product yield, good in optical purity and the like, and great guidance and application value is achieved in 1-acenaphthenol synthesis and splitting research.

Conventional chiralpak ID vs. capillary chiralpak ID-3 amylose tris-(3-chlorophenylcarbamate)-based chiral stationary phase columns for the enantioselective HPLC separation of pharmaceutical racemates

A comparative enantioselective analysis using immobilized amylose tris-(3-chlorophenylcarbamate) as chiral stationary phase in conventional high-performance liquid chromatography (HPLC) with Chiralpak ID (4.6mm ID×250mm, 5μm silica gel) and micro-HPLC with Chiralpak ID-3 (0.30mm ID×150mm, 3μm silica gel) was conducted. Pharmaceutical racemates of 12 pharmacological classes, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, dopamine antagonists, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, diuretics, antihistaminics, anticancer drugs, and antiarrhythmic drugs were screened under normal phase conditions. The effect of an organic modifier on the analyte retentions and enantiomer recognition was investigated. Baseline separation was achieved for 1-acenaphthenol, carprofen, celiprolol, cizolirtine carbinol, miconazole, tebuconazole, 4-hydroxy-3-methoxymandelic acid, 1-indanol, 1-(2-chlorophenyl)ethanol, 1-phenyl-2-propanol, flavanone, 6-hydroxyflavanone, 4-bromogluthethimide, and pentobarbital on the 4.6mm ID packed with a 5μm silica column using conventional HPLC. Nonetheless, baseline separation was achieved for aminoglutethimide, naftopidil, and thalidomide on the 0.3mm ID packed with a 3μm silica capillary column. Chirality 26:677-682, 2014.