124072-81-7 Usage
Description
(R)-N-BOC-N,N-DIMETHYL-L-PROLINAMIDE is a chemical compound derived from proline, belonging to the class of amides. It is widely recognized for its application as a chiral reagent in organic synthesis, particularly in asymmetric synthesis for the formation of chiral ketones and aldehydes. (R)-N-BOC-N,N-DIMETHYL-L-PROLINAMIDE holds significant importance in the production of chiral molecules, making it a valuable asset in the field of organic chemistry.
Uses
Used in Organic Synthesis:
(R)-N-BOC-N,N-DIMETHYL-L-PROLINAMIDE is used as a chiral reagent for the synthesis of chiral ketones and aldehydes, playing a crucial role in creating these essential molecules in organic chemistry.
Used in Pharmaceutical Compound Preparation:
(R)-N-BOC-N,N-DIMETHYL-L-PROLINAMIDE is also utilized in the preparation of pharmaceutical compounds, contributing to the development of various organic products that have medicinal applications.
Used in Asymmetric Synthesis:
In the field of asymmetric synthesis, (R)-N-BOC-N,N-DIMETHYL-L-PROLINAMIDE is employed as a key reagent, enabling the creation of enantiomerically pure compounds, which are vital for the pharmaceutical industry and other related fields.
Check Digit Verification of cas no
The CAS Registry Mumber 124072-81-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,0,7 and 2 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 124072-81:
(8*1)+(7*2)+(6*4)+(5*0)+(4*7)+(3*2)+(2*8)+(1*1)=97
97 % 10 = 7
So 124072-81-7 is a valid CAS Registry Number.
124072-81-7Relevant articles and documents
New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists
Yea, Christopher M.,Allan, Christine E.,Ashworth, Doreen M.,Barnett, James,Baxter, Andy J.,Broadbridge, Janice D.,Franklin, Richard J.,Hampton, Sally L.,Hudson, Peter,Horton, John A.,Jenkins, Paul D.,Penson, Andy M.,Pitt, Gary R. W.,Rivière, Pierre,Robson, Peter A.,Rooker, David P.,Semple, Graeme,Sheppard, Andy,Haigh, Robert M.,Roe, Michael B.
body text, p. 8124 - 8134 (2009/11/30)
Vasopressin (AVP) is a hormone that stimulates an increase in water permeability through activation of V2 receptors in the kidney. The analogue of AVP, desmopressin, has proven an effective drug for diseases where a reduction of urine output is desired. However, its peptidic nature limits its bioavailability. We report herein the discovery of potent, nonpeptidic, benzylurea derived agonists of the vasopressin V2 receptor. We describe substitutions on the benzyl group to give improvements in potency and subsequent modifications to the urea end group to provide improvements in solubility and increased oral efficacy in a rat model of diuresis. The lead compound 20e (VA106483) is reported for the first time and has been selected for clinical development.