125664-98-4

Basic information

• Product Name: (2R,3R)-1-((6R)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)-3-hydroxy-2-methyl-3-phenylpropan-1-one
• Synonyms: (2R,3R)-1-((6R)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)-3-hydroxy-2-methyl-3-phenylpropan-1-one
• CAS NO: 125664-98-4
• Molecular Weight: 377.505
• Mol File: 125664-98-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,3R)-1-((6R)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)-3-hydroxy-2-methyl-3-phenylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-1-((6R)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)-3-hydroxy-2-methyl-3-phenylpropan-1-one(125664-98-4)
• EPA Substance Registry System: (2R,3R)-1-((6R)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)-3-hydroxy-2-methyl-3-phenylpropan-1-one(125664-98-4)

Safety Data

• Hazardous Substances Data: 125664-98-4(Hazardous Substances Data)

Upstream product

• 125664-95-1 N-propionyl-(2R)-bornane-(10,2)-sultam 
• 100-52-7 benzaldehyde 
• 125664-99-5 N-<(2R,3S)-3-hydroxy-2-methylbutanoyl>bornane-10,2-sultam 

Downstream Products

• 25201-44-9 (1R,2S)-2-methyl-1-phenylbut-3-en-1-ol 
• 125665-04-5 (S)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-((R)-hydroxy-phenyl-methyl)-butan-1-one 
• 125665-04-5 N-<(2S,3S)-2-(hydroxybenzyl)butanoyl>bornane-10,2-sultam 
• 125665-04-5 N-<(2R,3R)-2-(hydroxybenzyl)butanoyl>bornane-10,2-sultam 
• 125665-04-5 (R)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-((S)-hydroxy-phenyl-methyl)-butan-1-one 
• 125685-29-2 (R)-2-[(R)-(tert-Butyl-dimethyl-silanyloxy)-phenyl-methyl]-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-hexan-1-one 
• 125665-18-1 (R)-2-[(R)-(tert-Butyl-dimethyl-silanyloxy)-phenyl-methyl]-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-butan-1-one 
• 125665-07-8 N-<(2R,3R)-2-(hydroxybenzyl)hexanoyl>bornane-10,2-sultam 
• 7087-77-6 (1R,2S)-2-methyl-1-phenyl-propane-1,3-diol 
• 94594-90-8 (2R)-bornane-10,2-sultam 
• 76549-05-8 methyl (2R,3R)-3-hydroxy-2-methyl-3-phenylpropanoate 

Relevant articles and documents

Stereodivergent total synthesis of Br-nannocystins underpinning the polyketide (10R,11S) configuration as a key determinant of potency

Continuing our investigation into the structure-activity relationship of antiproliferative macrocyclic nannocystins, we describe herein total synthesis of all four stereoisomers of Br-nannocystins as well as a simplified analogue varying at the polyketide C10 and C11 positions. Biological evaluation of these compounds against PANC1 cancer cell lines showed that both the (10R,11S) configuration and its associated two substituents are crucial for high potency.

Bornanesultam-directed asymmetric synthesis of crystalline, enantiomerically pure syn aldols

N-acylsultams 2 furnish, via aldolization of their enolates 16 with aldehydes, diastereomerically pure, crystalline syn aldols. The absolute configuration of the product is controlled by the choice of the enolate counterion: 16, M = B → 3; 16, M = Li or S