135820-77-8

Basic information

• Product Name: 1-(4'-hydroxy-3'-methoxyphenyl)-2-<4''-(3-hydroxypropyl)-2''-methoxyphenoxy>-1,3-propanediol
• CAS NO: 135820-77-8
• Molecular Weight: 378.422
• Mol File: 135820-77-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(4'-hydroxy-3'-methoxyphenyl)-2-<4''-(3-hydroxypropyl)-2''-methoxyphenoxy>-1,3-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4'-hydroxy-3'-methoxyphenyl)-2-<4''-(3-hydroxypropyl)-2''-methoxyphenoxy>-1,3-propanediol(135820-77-8)
• EPA Substance Registry System: 1-(4'-hydroxy-3'-methoxyphenyl)-2-<4''-(3-hydroxypropyl)-2''-methoxyphenoxy>-1,3-propanediol(135820-77-8)

Safety Data

• Hazardous Substances Data: 135820-77-8(Hazardous Substances Data)

Usage

Description

1-(4'-hydroxy-3'-methoxyphenyl)-2-<4''-(3-hydroxypropyl)-2''-methoxyphenoxy>-1,3-propanediol is a complex organic chemical compound characterized by its unique structure. It features a propanediol backbone with multiple functional groups, including two hydroxyl (-OH) groups, a phenol group with a hydroxyl group attached to an aromatic ring, a methoxy group consisting of a methyl group linked to an oxygen atom, and a hydroxypropyl group with a propyl chain and a hydroxyl group attached to one of its carbon atoms. This intricate molecular architecture endows the compound with a wide range of potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
1-(4'-hydroxy-3'-methoxyphenyl)-2-<4''-(3-hydroxypropyl)-2''-methoxyphenoxy>-1,3-propanediol is used as a pharmaceutical intermediate for the synthesis of various drugs and active pharmaceutical ingredients. Its multiple functional groups and unique structure make it a versatile building block in the development of new therapeutic agents.
Used in Cosmetics Industry:
In the cosmetics industry, 1-(4'-hydroxy-3'-methoxyphenyl)-2-<4''-(3-hydroxypropyl)-2''-methoxyphenoxy>-1,3-propanediol is used as a key ingredient in various formulations due to its emollient, moisturizing, and skin-conditioning properties. Its hydroxyl and methoxy groups contribute to its ability to improve skin hydration and elasticity.
Used in Chemical Synthesis:
1-(4'-hydroxy-3'-methoxyphenyl)-2-<4''-(3-hydroxypropyl)-2''-methoxyphenoxy>-1,3-propanediol is utilized as a starting material or intermediate in the synthesis of various organic compounds, including specialty chemicals, dyes, and polymers. Its reactive functional groups facilitate a range of chemical reactions, enabling the creation of diverse chemical products.
Used in Material Science:
In the field of material science, 1-(4'-hydroxy-3'-methoxyphenyl)-2-<4''-(3-hydroxypropyl)-2''-methoxyphenoxy>-1,3-propanediol is employed as a component in the development of advanced materials, such as polymers, coatings, and adhesives. Its unique structure and functional groups contribute to the properties of these materials, enhancing their performance and versatility.
Used in Analytical Chemistry:
1-(4'-hydroxy-3'-methoxyphenyl)-2-<4''-(3-hydroxypropyl)-2''-methoxyphenoxy>-1,3-propanediol serves as a reference compound or standard in analytical chemistry for the calibration of instruments and the development of analytical methods. Its well-defined structure and properties make it suitable for use in the accurate measurement and quantification of related compounds.

Upstream product

• 186581-53-3 diazomethane 
• 261778-30-7 1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol 
• 97055-96-4 1-(4-hydroxy-3-methoxyphenyl)-2-<4-(3-rhamnopyranoxypropyl)-2-methoxyphenoxy>-1,3-propanediol (threo) 
• 1009838-89-4 (7R,8S)-erythro-7,9,9'-tirhydroxy-3,3'-dimethoxy-8-O-4'-neolignan-4-O-β-D-glucopyranoside 

Downstream Products

• 2305-13-7 3-Guaiacylpropanol 

Relevant articles and documents

Neolignan glycosides from Symplocos caudata

A phytochemical investigation of the roots of Symplocos caudata Wall (Symplocaceae) resulted in isolation and characterization of four optical isomers of a neolignan glycoside (1-4), a lignan lactone glycoside (5), a phenylpropanoid glycoside (6), as well as two known compounds (7, 8). Their structures were elucidated as (7S,8S)-threo-7,9,9′-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-4-O-β-d-glucopyranoside (1), (7R,8R)-threo-7,9,9′-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-4-O-β-d-glucopyranoside (2), (7R,8S)-erythro-7,9,9′-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-4-O-β-d-glucopyranoside (3), (7S,8R)-erythro-7,9,9′-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-4-O-β-d-glucopyranoside (4), 8R,8′R-matairesinol-4-O-β-d-xylopyranosyl-(1 → 2)-O-β-d-glucopyranoside (5), 1-O-[β-d-xylopyranosyl-(1 → 6)-O-β-d-glucopyranosyl]-2,6-dimethoxy-4-propenyl-phenol (6), matairesinoside (7), and (R)-1-O-(β-d-glucopyranosyl)-2-[2-methoxy-4-(ω-hydroxypropyl)-phenoxyl]-propan-3-ol (8) on the basis of spectroscopic data (1D and 2D NMR, MS and CD) and chemical evidence.

Discovery of Neolignan Glycosides with Acetylcolinesterase Inhibitory Activity from Huangjinya Green Tea Guided by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry Data and Global Natural Product Social Molecular Networking

Global Natural Product Social feature-based networking was applied to follow the phytochemicals, including nine flavonoid glycosides, six catechins, and three flavonols in Huangjinya green tea. Further, a new 8-O-4′-type neolignan glycoside, camellignanoside A (1), and 15 known compounds (2-16) were isolated through a variety of column chromatographies, and the structure was elucidated extensively by ultra performance liquid chromatography-quadrupole-time-of-flight-tandem mass spectrometry, 1H and 13C nuclear magnetic resonance, heteronuclear single-quantum correlation, heteronuclear multiple-bond correlation, 1H-1H correlation spectroscopy, rotating frame nuclear Overhauser effect spectroscopy, and Nuclear Overhauser effect spectroscopy, and circular dichroism spectroscopies. Compounds 1 and 2 showed acetylcolinesterase inhibition activity, with IC50 = 0.75 and 0.18 μM, respectively.

The Constituents of Conifer Needles. Dilignol Glycosides from Pinus massoniana Lamb.

Seventeen dilignol glycosides and two arylglycerols have been isolated and identified from Pinus massoniana Lamb. needles.They consisted of two α-L-rhamnopyranosides of 2,3-dihydro-2-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-7-methoxy-5-benzofuranpropanol; two α-L-rhamnopyranosides and a β-D-glucopyranoside of 2,3-dihydro-7-hydroxy-2-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-5-benzofuranpropanol; an α-L-rhamnopyranoside, two β-D-glucopyranosides and a β-D-xyloparanoside of 1-(4'-hydroxy-3'-methoxyphenyl)-2--1,3-propanediol; an α-L-rhamnopyranoside and a β-D-glucopyranoside of 1-(4'-hydroxy-3'-methoxyphenyl)-2--1,3-propanediol; a β-D-xylopyranoside, a β-D-glucopyranoside and an α-L-arabinofuranoside of (+)-isolariciresinol; a β-D-glucopyranoside and a β-D-xylopyranoside of (-)-seco-isolariciresinol and a β-D-glucopyranoside of (+)-pinoresinol.The two arylglycerols were 1-(4-hydroxyphenyl)-1,2,3-propanetriol and 1-(4-hydroxy-3-methoxyphenyl)-1,2,3-propanetriol.In this communication, we describe the identification of a series of dilignol glycosides and two arylglycerols, isolated together with some flavonoids 1 and a new lignan, 2 from Pinus massoniana Lamb.