142274-09-7

Basic information

• Product Name: butyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate
• Synonyms: butyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate
• CAS NO: 142274-09-7
• Molecular Weight: 215.249
• Mol File: 142274-09-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: butyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: butyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate(142274-09-7)
• EPA Substance Registry System: butyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate(142274-09-7)

Safety Data

• Hazardous Substances Data: 142274-09-7(Hazardous Substances Data)

Upstream product

• 142274-08-6 (4-ethoxy-1,5-dihydro-2-oxo-2H-pyrrol-1-yl)acetic acid 
• 142274-11-1 2,4-dioxopyrrolidin-1-yl-acetic acid 
• 71-36-3 butan-1-ol 

Downstream Products

• 68252-28-8 oxiracetam 

Relevant articles and documents

Oxiracetam preparation method

An oxiracetam preparation method comprises the following steps: (a) azidation reaction of 4-chloro-3-hydroxybutyrate as a starting material and an azidation reagent to obtain an give intermediate I; (2) reduction reaction of the intermediate I to obtain an intermediate II; (2) condensation reaction of the intermediate II and a halogenated acetic acid ester to obtain an intermediate III; (3) ring closing reaction of the intermediate III to obtain an intermediate IV; and (4) aminolysis reaction of the intermediate IV to obtain desired product oxiracetam. The desired product oxiracetam with an ideal yield of at least more than 38% can be obtained, and a new oxiracetam synthetic route is opened up.

An efficient synthesis of racemic 4-hydroxy-2-oxo-1-pyrrolidineacetamide (oxiracetam) using tetramic-acid intermediates

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