143120-46-1 Usage
Description
Neotuberostemonine (NTS) is a prominent antitussive alkaloid found in the root of Stemona tuberosa Lour, a plant known for its medicinal properties. It exhibits significant protective effects on bleomycin (BLM)-induced pulmonary fibrosis by inhibiting the recruitment and M2 polarization of macrophages. Additionally, NTS demonstrates antitussive properties in guinea pigs, making it a valuable compound for respiratory health.
Uses
Used in Pharmaceutical Industry:
Neotuberostemonine is used as a therapeutic agent for treating pulmonary fibrosis due to its protective effects against BLM-induced fibrosis. It helps in suppressing the recruitment and M2 polarization of macrophages, which play a crucial role in the development of fibrosis.
Neotuberostemonine is also used as an antitussive agent for the treatment of cough in guinea pigs, showcasing its potential in managing respiratory conditions.
Used in Research and Development:
In the field of pharmaceutical research and development, Neotuberostemonine serves as a key compound for studying its antitussive properties and potential applications in developing new drugs for respiratory disorders. Its protective effects on pulmonary fibrosis also make it a valuable subject for research into the underlying mechanisms of fibrosis and the development of targeted therapies.
Biological Functions
Neotuberostemonine is an alkaloid originally isolated from S. tuberosa that has diverse biological activities. It inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at a concentration of 100 μM. Neotuberostemonine (50 μM) inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells. It reduces the citric acid-induced cough reflex in conscious guinea pigs when administered at a dose of 133 μmol/kg. Neotuberostemonine (40 mg/kg) inhibits pulmonary collagen deposition and fibrosis, as well as bronchoalveolar lavage fluid (BALF) monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis.
Biological Activity
Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages.
Check Digit Verification of cas no
The CAS Registry Mumber 143120-46-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,1,2 and 0 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 143120-46:
(8*1)+(7*4)+(6*3)+(5*1)+(4*2)+(3*0)+(2*4)+(1*6)=81
81 % 10 = 1
So 143120-46-1 is a valid CAS Registry Number.