151832-39-2

Basic information

• Product Name: N-(α-benzotriazol-1-ylmethyl)phenylacetamide
• Synonyms: N-(α-benzotriazol-1-ylmethyl)phenylacetamide
• CAS NO: 151832-39-2
• Molecular Weight: 342.4
• Mol File: 151832-39-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(α-benzotriazol-1-ylmethyl)phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(α-benzotriazol-1-ylmethyl)phenylacetamide(151832-39-2)
• EPA Substance Registry System: N-(α-benzotriazol-1-ylmethyl)phenylacetamide(151832-39-2)

Safety Data

• Hazardous Substances Data: 151832-39-2(Hazardous Substances Data)

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 100-52-7 benzaldehyde 
• 103-81-1 Benzeneacetamide 

Downstream Products

• 10254-16-7 N-diphenylmethylphenylacetamide 
• 17507-05-0 1-phenyl-1,4-dihydro-3(2H)-isoquinolinone 

Relevant articles and documents

1-Aryl-1,4-dihydro-3(2H)-isoquinolinones: Two modes of interaction with 5-HT(1A) receptors

Two series of 1-aryl-1,4-dihydro-3(2H)-isoquinoline derivatives were synthesized, and their in vitro and in vivo properties at 5-HT(1A) and 5- HT(2A) receptors were evaluated. In was shown that series a, containing a 1- (m-chlophenyl)piperazine fragment, interacts with 5-HT(1A) receptors in two different modes: as an ordinary 4-substituted 1-arylpiperazine and as a pseudo one. Series b, with a 1,2,3,4-tetrahydroisoquinoline moiety, binds to the receptor thanks to a pseudo 1-arylpiperazine fragment. Regardless of the mode of interaction, both those series demonstrated 5-HT(1A) receptor antagonistic properties in animal models. Different in vivo properties of 2b, due to a 7-methoxy substituent, indicate that the isoquinolinone portion also interacts with 5-HT(1A) receptors.