1539-57-7

Basic information

• Product Name: 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester
• Synonyms: 1,4-Dihydro-2,6-dimethyl-4-benzyl-3,5-pyridinedicarboxylic acid diethyl ester;1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester;2,6-Dimethyl-4-benzyl-1,4-dihydro-3,5-pyridinedicarboxylic acid diethyl ester;2,6-Dimethyl-4-benzyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester;4-Benzyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
• CAS NO: 1539-57-7
• Molecular Formula: C₂₀H₂₅NO₄
• Molecular Weight: 343.4168
• Mol File: 1539-57-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 460.3°Cat760mmHg
• Flash Point: 232.2°C
• Appearance: /
• Density: 1.116g/cm³
• Vapor Pressure: 1.18E-08mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester(1539-57-7)
• EPA Substance Registry System: 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester(1539-57-7)

Safety Data

• Hazardous Substances Data: 1539-57-7(Hazardous Substances Data)

Usage

Description

1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester is a complex organic chemical compound characterized by its pyridine ring with two methyl substituents and a benzyl group. It is a diester of a pyridine dicarboxylic acid, known for its potential applications in various scientific fields, including pharmaceuticals, agrochemicals, and materials science. 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester's unique structure and properties have garnered interest for its potential as an antioxidant, anti-inflammatory agent, and in the treatment of neurodegenerative diseases such as Alzheimer's, making it a promising candidate for research and development in medicinal chemistry and drug discovery.

Uses

Used in Pharmaceutical Applications:
1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester is used as a potential therapeutic agent for neurodegenerative diseases such as Alzheimer's due to its potential neuroprotective properties. Its unique structure may contribute to its ability to mitigate oxidative stress and inflammation, which are key factors in the progression of such diseases.
Used in Antioxidant Formulations:
As an antioxidant, 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester is used to protect cells from oxidative damage, which is a common pathological feature in many diseases and conditions. Its antioxidant properties may be leveraged in the development of pharmaceuticals and supplements to combat oxidative stress.
Used in Anti-Inflammatory Agents:
1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester is used as an anti-inflammatory agent, potentially reducing inflammation in various conditions. Its structure may allow it to modulate inflammatory pathways, offering a new approach to treating inflammatory diseases.
Used in Agrochemical Development:
In the agrochemical industry, 1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester may be used as a component in the development of new pesticides or herbicides. Its chemical properties could provide novel modes of action against pests and weeds, enhancing crop protection strategies.
Used in Materials Science:
1,4-Dihydro-2,6-dimethyl-4-benzylpyridine-3,5-dicarboxylic acid diethyl ester's unique structure may also find applications in materials science, potentially serving as a component in the development of new polymers or other materials with specific properties, such as improved stability or reactivity.

InChI:InChI=1/C20H25NO4/c1-5-24-19(22)17-13(3)21-14(4)18(20(23)25-6-2)16(17)12-15-10-8-7-9-11-15/h7-11,16,21H,5-6,12H2,1-4H3

Upstream product

• 122-78-1 phenylacetaldehyde 
• 141-97-9 ethyl acetoacetate 
• 626-34-6 ethyl aminocrotonate 
• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 
• 140429-21-6 N-(1-chloro-2-phenylethyl)pyridinium chloride 
• 36873-30-0 2-benzyl-4,4,6-trimethyltetrahydro-(2H)-1,3-oxazine 
• 57-13-6 urea 

Downstream Products

• 1149-24-2 2,6-dimethyl-pyridine-3,5-dicarboxylic acid diethyl ester 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 
• 65-85-0 benzoic acid 
• 16035-87-3 N-(p-nitrobenzyl)-p-anisidine 
• 1834-74-8 (1,2-diphenyl-ethyl)-(4-methoxy-phenyl)amine 
• 436087-20-6 N-(1-(furan-2-yl)-2-phenylethyl)-4-methoxyaniline 
• 75473-94-8 (E)-(non-2-en-1-yl)benzene 
• 100-39-0 benzyl bromide 
• 451-40-1 phenyl benzyl ketone 
• 2001-28-7 2-phenyl-1-p-tolyl-ethanone 

Relevant articles and documents

Enantioselective Alkylamination of Unactivated Alkenes under Copper Catalysis

An enantioselective addition reaction of various alkyl groups to unactivated internal alkenes under Cu catalysis has been developed. The reaction uses amide-linked aminoquinoline as the directing group, 4-alkyl Hantzsch esters as the donor of alkyl radicals, and rarely used biaryl diphosphine oxide as a chiral ligand. β-lactams featuring two contiguous stereocenters at Cβ and the β substituent can be obtained in good yield with excellent enantioselectivity. Mechanistic studies indicate that a nucleophilic addition of the alkyl radical to CuII-coordinated alkene is the enantio-determining step.

USE OF COMPOSITIONS OBTAINED BY CALCINING PARTICULAR METAL-ACCUMULATING PLANTS FOR IMPLEMENTING CATALYTICAL REACTIONS

The use of metal-accumulating plants for implementing chemical reactions especially catalytical reactions.

Novel syntheses of heterocycles with N-(1-haloalkyl)azinium halides. Part 2. Preparation of N-unsubstituted 1,4-dihydropyridines

N-(1-Chloroalkyl)pyridinium chlorides, prepared from thionyl chloride, pyridine, and aldehydes, readily react with enaminocarbonyl derivatives to yield 1,4-dihydropyridines under mild and neutral conditions.