15930-53-7Relevant articles and documents
Synthesis and Biological Evaluation of Benzo[d][1,3]Dioxol-5-yl Chalcones as Antiproliferating Agents
Kamal, Ahmed,Balakrishna, Moku,Loka Reddy, Velatooru,Riyaz, Syed,Bagul, Chandrakant,Satyanarayana, Bethu Murali,Venkateswar Rao, Janapala
, p. 1267 - 1284 (2015)
A series of chalcone derivatives were designed, synthesized, and evaluated for their cytotoxic potential. These molecules have showed promising cytotoxic activity with IC50 values ranging from 5.24 to 63.12 μm. Among them, conjugates 16k, 16m a
DNA binding ligands with in vivo efficacy in murine models of bacterial infection: Optimization of internal aromatic amino acids
Buerli, Roland W.,Kaizerman, Jacob A.,Duan, Jian-Xin,Jones, Peter,Johnson, Kirk W.,Iwamoto, Mari,Truong, Kiet,Hu, Wenhao,Stanton, Timothy,Chen, Alfred,Touami, Sofia,Gross, Matthew,Jiang, Vernon,Ge, Yigong,Moser, Heinz E.
, p. 2067 - 2072 (2004)
DNA binding ligands with potent antimicrobial activity against Gram-positive bacteria were further optimized by variation of the internal aromatic amino acids. This modification led to compounds with improved in vivo efficacy in lethal murine models of peritonitis (methicillin-resistant S. aureus, MRSA) and lung infection (S. pneumoniae).
Total synthesis of enantiopure (+)-γ-lycorane using highly efficient Pd-catalyzed asymmetric allylic alkylation
Chapsal, Bruno D.,Ojima, Iwao
, p. 1395 - 1398 (2006)
A highly efficient short total synthesis of (+)-γ-lycorane (>99% ee, 41% overall yield) was achieved by using the asymmetric allylic alkylation in the key step catalyzed by palladium complexes with novel chiral biphenol-based monodentate phosphoramidite l
DIHYDROCYCLOPENTA-ISOQUINOLINE-SULFONAMIDE DERIVATIVES COMPOUNDS
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Page/Page column 38, (2021/07/02)
The present invention relates to dihydrocyclopenta-isoquinoline-sulfonamide derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use in treating disorders caused by IgE (such as allergic responses, non-allergic mast cell responses or certain autoimmune responses), and in particular disorders caused by the interaction of IgE with the FcεRI receptor.
COMPOUNDS FOR THE INHIBITION OF UNREGULATED CELL GROWTH
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Page/Page column 43, (2020/07/14)
The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly cancer stem cells. Particularly, the invention relates to compounds of Formula I to XXII for the treatment of cancer.