159547-14-5Relevant articles and documents
Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes
Chang,Ashton,Flanagan,Chen,O'Malley,Zingaro,Kivlighn,Siegl,Lotti,Chang,Greenlee
, p. 3741 - 3758 (2007/10/03)
In order to block the effects induced by the interactions between angiotensin II (AII) and both AT1 and AT2 receptors, we have pursued the discovery of orally active non-peptide AII antagonists that exhibit potent and equal affinity
Triazolinone Biphenylsulfonamides as Angiotensin II Receptor Antagonists with High Affinity for Both the AT1 and AT2 Subtypes
Chang, Linda L.,Ashton, Wallace T.,Flanagan, Kelly L.,Chen, Tsing-Bau,O'Malley, Stacey S.,et al.
, p. 4464 - 4478 (2007/10/02)
Angiotensin II (AII), the endogenous peptide ligand of the AII receptor, has equivalent high affinity for both the AT1 and AT2 receptor subtypes while most of the reported nonpeptide AII antagonists are AT1-selective.In an