20330-45-4

Basic information

• Product Name: 4'-(TERT-BUTYL)ACETANILIDE
• Synonyms: Acetanilide, 4'-tert-butyl-;4'-(TERT-BUTYL)ACETANILIDE;N-(4-TERT-BUTYLPHENYL)ACETAMIDE;N1-[4-(TERT-BUTYL)PHENYL]ACETAMIDE;P-TERT-BUTYLACETANILIDE;TIMTEC-BB SBB007960;tert-Butylacetanilide;4-t-Butylacetanilide
• CAS NO: 20330-45-4
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.27
• Mol File: 20330-45-4.mol
• Article Data: 41

Chemical Properties

• Melting Point: 168-170°C
• Boiling Point: 333.1 °C at 760 mmHg
• Flash Point: 198.5 °C
• Appearance: /
• Density: 1.01 g/cm³
• Vapor Pressure: 0.000139mmHg at 25°C
• Refractive Index: 1.535
• PKA: 15.13±0.70(Predicted)
• CAS DataBase Reference: 4'-(TERT-BUTYL)ACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(TERT-BUTYL)ACETANILIDE(20330-45-4)
• EPA Substance Registry System: 4'-(TERT-BUTYL)ACETANILIDE(20330-45-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 20330-45-4(Hazardous Substances Data)

Usage

Uses

4''-(tert-Butyl)acetanilide is a useful intermediate for organic synthesis.

InChI:InChI=1/C12H17NO/c1-9(14)13-11-7-5-10(6-8-11)12(2,3)4/h5-8H,1-4H3,(H,13,14)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 103-84-4 Acetanilid 
• 769-92-6 4-tert-Butylaniline 
• 75-36-5 acetyl chloride 
• 507-20-0 tertiary butyl chloride 
• 78-77-3 Isobutyl bromide 
• 3282-56-2 4-tert-butylnitrobenzene 
• 7664-93-9 sulfuric acid 
• 93971-54-1 4-tert-butylacetophenone oxime 
• 108-24-7 acetic anhydride 
• 772-38-3 4-tert-Butylphenylacetylene 
• 6637-03-2 1-(tert-butyl)-4-nitrosobenzene 
• 431-03-8 dimethylglyoxal 
• 75-05-8 acetonitrile 

Downstream Products

• 68176-57-8 4-(tert-butyl)-1,2-diaminobenzene 
• 2359-09-3 5-t-butylisophthalic acid 
• 3972-55-2 1-tert-butyl-3-chloro-benzene 
• 22385-63-3 1-tert-butyl-3,5-dinitro-benzene 
• 500878-03-5 3-tert-butyl-5-nitro-aniline 
• 7498-54-6 3-t-Butylbenzoic acid 
• 109774-64-3 Acetyl-(4-tert-butyl-phenyl)-carbamic acid tert-butyl ester 
• 769-92-6 4-tert-Butylaniline 
• 6310-19-6 4-tert-butyl-2-nitroaniline 
• 100141-30-8 acetic acid-(4-tert-butyl-2-chloro-anilide) 
• 42265-67-8 4-t-butyl-2-chloroaniline 
• 40655-37-6 N-(4-(tert-butyl)-2-nitrophenyl)acetamide 
• 91801-97-7 N-(2-bromo-4-tert-butylphenyl)acetamide 
• 22503-15-7 N-(4-(tert-butyl)-2,6-dinitrophenyl)acetamide 

Relevant articles and documents

Metal complexes of tetra(6-tert-butyl-2,3-quinolino)porphyrazine: I. Synthesis

Complexes of tetra(6-tert-butyl-2,3-quinolino)porphyrazine with Cu, Co, Zn, and Ni soluble in hydrophobic liquids were synthesized for the first time by template tetramerization of derivatives of 6-tert-butylquinoline-2,3- dicarboxylic acid formed from the corresponding acid in the course of carbamide synthesis in presence of the bivalent metal ions.

Method for promoting acylation of amine or alcohol by carbon dioxide

The invention relates to a method for promoting acylation of amine or alcohol by carbon dioxide, which comprises the following steps of: mixing an amine compound, carboxylate or thiocarboxylate compound and a reaction solvent under the action of carbon dioxide, and reacting to obtain an amide compound, or under the action of carbon dioxide, mixing the alcohol compound, the thiocarboxylate compound and the reaction solvent [gamma]-valerolactone, and reacting to obtain the ester compound. According to the invention, under the promotion action of carbon dioxide, carboxylate or thiocarboxylate is used as an acylation reagent, and amine and alcohol are converted into amide and ester compounds in the absence of a transition metal catalyst, so that acylation reagents such as acyl chloride or anhydride with irritation and corrosivity are avoided; and the method has the advantages of simple operation, mild reaction conditions, high tolerance of substrate functional groups, strong applicability and high yield, and provides an efficient, reliable and economical preparation method for synthesis of amide and ester compounds.

Quantification of cooperativity in the self-assembly of H-bonded rosettes

The self-assembly of triaminopyrimidines with barbiturates and with cyanates was investigated in chloroform solution. Equimolar mixtures of two complementary components form stable macrocyclic 3:3 complexes (rosettes). The thermodynamics of self-assembly were quantified by using 1H NMR titrations to measure the strength of pairwise H-bonding interactions between two rosette components (K), allosteric cooperativity associated with formation of a second H-bonding interaction with each component, and the effective molarity for cyclisation of the rosette motif (EM). Pyrimidine-cyanurate interactions are an order of magnitude more favourable than pyrimidine-barbiturate interactions, so the cyanurate rosettes are significantly more stable than barbiturate rosettes. There is no allosteric cooperativity associated with rosette formation, but the chelate cooperativity quantified by the product K EM is exceptionally high (102-104), indicating that there are no other species present that compete with rosette assembly. The values of EM for rosette formation are approximately 2 M for all four rosettes studied and are not affected by differences in peripheral substituents or intrinsic H-bond strength.

Catalyst-free, direct electrochemical synthesis of annulated medium-sized lactams through C-C bond cleavage

A catalyst-free, direct electrochemical synthesis of synthetically challenging medium-sized lactams through C-C bond cleavage has been developed. In contrast to previous typical amidyl radical cyclization, this electrosynthetic approach enabled step-economical ring expansion through a unique remote amidyl migration under mild, metal- and external-oxidant-free conditions in a simple undivided cell. The strategy features unparalleled broad substrate scope with all ring sizes of (hetero)aryl-fused 8-11-membered rings and hetero atom-tethered rings, high yields, and good functional group tolerance. Our experimental and computational findings provided strong support for a SET-based reaction manifold.