27646-80-6

Basic information

• Product Name: 1-Propanol, 2-methyl-2-(methylamino)-
• Synonyms: 1-Propanol, 2-methyl-2-(methylamino)-;2-methyl-2-(methylamino)-1-Propanol;2-(METHYLAMINO)-2-METHYL-1-PROPANOL;2-Methyl-2-methylaminopropan-1-ol;N-(2-Hydroxy-1,1-dimethylethyl)-N-methylamine;NSC 147612
• CAS NO: 27646-80-6
• Molecular Formula: C₅H₁₃NO
• Molecular Weight: 103.17
• Mol File: 27646-80-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 162℃
• Flash Point: 62℃
• Appearance: /
• Density: 0.878
• Vapor Pressure: 0.755mmHg at 25°C
• Refractive Index: 1.429
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 15.90±0.10(Predicted)
• CAS DataBase Reference: 1-Propanol, 2-methyl-2-(methylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanol, 2-methyl-2-(methylamino)-(27646-80-6)
• EPA Substance Registry System: 1-Propanol, 2-methyl-2-(methylamino)-(27646-80-6)

Safety Data

• Hazardous Substances Data: 27646-80-6(Hazardous Substances Data)

Usage

Uses

2-Methyl-2-(methylamino)propan-1-ol functions as an antimicrobial agent for metal-working lubricant oils.

InChI:InChI=1/C5H13NO/c1-5(2,4-7)6-3/h6-7H,4H2,1-3H3

Upstream product

• 102520-97-8 2-((tert-butyloxycarbonyl)amino)-2-methylpropan-1-ol 
• 58743-30-9 2-Methyl-2-(methylamino)propionsaeure-ethylester 

Downstream Products

• 94914-87-1 Benzilsaeure-<2-methyl-2-methylamino-propylester> 
• 1242652-49-8 2-(4-amino-3,5-dichlorophenyl)-4,5,5-trimethylmorpholin-2-ol 
• 1620578-12-2 7-((3-fluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one 

Relevant articles and documents

2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

N-Alkyl-5,5-dimethyl-2-oxomorpholin-3-yl radicals. Characterization and reaction with molecular oxygen

The synthesis of bi(4,5,5-trimethyl-2-oxomorpholin-3-yl) (TM-3′ dimer), bi(5,5-dimethyl-4-cthyl-2-oxomorpholin-3-yl) (DEM-3 dimer), and bi(5,5-dimethyl-4-isopropyl-2-oxomorpholin-3-yl) (DIM-3 dimer) by one-electron oxidation of 4,5,5-trimethyl-2-oxomorpholine (8), 5,5-dimethyl-4-ethyl-2-oxomorpholine (9), and 5,5-dimethyl-4-isopropyl-2-oxomorpholine (10), respectively, with photochemically generated rert-butoxyl radical is described. dl-TM-3′ dimer, meso-DEM-3 dimer, and meso-DIM-3 dimer were characterized from spectra and by X-ray crystallography. In solution the radical dimers existed in equilibrium with the captodatively substituted radicals, 4,5,5-trimethyl-2-oxomorpholin-3-yl (TM-3′), 5,5-dimethyl-4-ethyl-2-oxomorpholin-3-yl (DEM-3), and 5,5-dimethyl-4-isopropyl-2-oxomorpholin-3-yl (DIM-3), respectively, as indicated by EPR spectroscopy. The activation parameters for bond homolysis in ethanol solvent were measured by oxidatively trapping the radicals with diphenylpicrylhydrazyl (DPPH). The half-lives for bond homolysis vary by S orders of magnitude at 25°C with a value of only 2.3 s for DIM-3 dimer. DIM-3 dimer reacted quantitatively with molecular oxygen to form a mixture of meso- and dl-bis(5,5-dimethyl-4-isopropyl-2-oxomorpholin-3-yl) peroxides (DIM-3 peroxides), which were isolated and characterized spectroscopically and analytically. At ambient temperature the peroxides fragmented by C-O bond homolysis to release the DIM-3 radical as indicated by EPR spectroscopy and were solvolyzed by protic solvent with release of hydrogen peroxide. The solvolysis was reversed by evaporation of the protic solvent, which restored most of the DIM-3 peroxides. The peroxides also slowly fragmented irreversibly to 5,5-dimethyl-3-hydroxy-4-isopropyl-2-oxomorpholine (21) and 5,5-dimethyl-2,3-dioxo-4-isopropylmorpholine (23) in polar aprotic solvent.