33241-96-2Relevant articles and documents
Synthesis of Lactams by Reductive Amination of Carbonyl Derivatives with ω-Amino Fatty Acids under Hydrosilylation Conditions
Tongdee, Satawat,Wei, Duo,Wu, Jiajun,Netkaew, Chakkrit,Darcel, Christophe
supporting information, p. 5536 - 5539 (2021/08/07)
An efficient method for the preparation of lactams from ω-amino fatty acids under hydrosilylation is described. A variety of lactams such as pyrrolidinones, piperidinones and 2-azepanones were selectively synthesised in moderate to excellent yields (29 examples, up to 95 % isolated yields) with a good functional group tolerance. Notably, no metallic based catalyst was required to perform this transformation.
A Unified Strategy for the Synthesis of Difluoromethyl- And Vinylfluoride-Containing Scaffolds
Duchemin, Nicolas,Buccafusca, Roberto,Daumas, Marc,Ferey, Vincent,Arseniyadis, Stellios
supporting information, p. 8205 - 8210 (2019/10/16)
Here, we report a general method for the synthesis of quaternary and tertiary difluoromethylated compounds and their vinylfluoride analogues. The strategy, which relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and either a palladium-catalyzed decarboxylative protonation or a Krapcho decarboxylation, is practical, scalable, and high yielding. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.
Purification method for DL-alpha-amino caprolactam
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Paragraph 0019-0039, (2019/02/21)
The invention belongs to the technical field of the organic matter purification technology, and particularly relates to a purification method for DL-alpha-amino caprolactam. The preparation method comprises the following steps: S1: dissolving alpha-halogenated caprolactam and benzylamine in an organic solvent, adding alkali, controlling reaction temperature, and reacting to generate N-benzyl-DL-alpha-amino caprolactam; S2: adding the N-benzyl-DL-alpha-amino caprolactam generated by reaction in S1 into a reflux solvent, then, adding a catalyst and a hydrogen supply reagent, and carrying out reflux reaction to prepare a DL-alpha-amino caprolactam coarse product; S3: heating and dissolving the prepared DL-alpha-amino caprolactam coarse product by a recrystallization solvent, removing impurities during hotness, cooling, filtering, and taking solid, i.e. purified DL-alpha-amino caprolactam, wherein the recrystallization solvent is a mixed solvent obtained by mixing ethyl acetate, tetrahydrofuran and cyclohexanone at the mass ratio of (15-20):(6-8):5.