33528-13-1

Basic information

• Product Name: N-BENZYL-N-NITROSO-P-TOLUENESULFONAMIDE
• Synonyms: N-Benzyl-N-nitroso-p-toluenesulfonamide;N-benzyl-4-methyl-N-nitrosobenzenesulfonamide
• CAS NO: 33528-13-1
• Molecular Formula: C₁₄H₁₄N₂O₃S
• Molecular Weight: 290.34
• Product Categories: Nitrogen Compounds;Nitroso Compounds;Organic Building Blocks
• Mol File: 33528-13-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 85 °C
• Boiling Point: 438.7°C at 760 mmHg
• Flash Point: 219.1°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 6.79E-08mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Refrigerator
• Solubility: soluble in Toluene
• CAS DataBase Reference: N-BENZYL-N-NITROSO-P-TOLUENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZYL-N-NITROSO-P-TOLUENESULFONAMIDE(33528-13-1)
• EPA Substance Registry System: N-BENZYL-N-NITROSO-P-TOLUENESULFONAMIDE(33528-13-1)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 33528-13-1(Hazardous Substances Data)

Usage

General Description

N-Benzyl-N-nitroso-p-toluenesulfonamide is a chemical compound with the molecular formula C14H14N2O4S. It is commonly used as a rubber chemical accelerator and is used in the production of rubber products such as tires and hoses. It is also used as an intermediate in the synthesis of various pharmaceuticals. N-BENZYL-N-NITROSO-P-TOLUENESULFONAMIDE is known to have carcinogenic properties and should be handled and used with caution. Its chemical structure and properties make it useful in a variety of industrial applications, but proper safety precautions should be taken when handling this chemical.

InChI:InChI=1/C14H14N2O3S/c1-12-7-9-14(10-8-12)20(18,19)16(15-17)11-13-5-3-2-4-6-13/h2-10H,11H2,1H3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 1576-37-0 N-benzyl-p-toluenesulfonamide 

Downstream Products

• 35638-83-6 (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-5-(hydroxymethyl) tetrahydrofuran-3-ol 
• 35638-82-5 (2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-5-(hydroxymethyl) tetrahydrofuran-3-ol 
• 1341220-44-7 (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-5-(chloromethyl)tetrahydrofuran-3-ol 
• 1341220-46-9 (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-3-(benzyloxy)-5-(chloromethyl)tetrahydrofuran-4-ol 
• 1341220-49-2 9-((2R,3R,4S,5S)-3,4-bis(benzyloxy)-5-(chloromethyl)tetrahydrofuran-2-yl)-9H-purin-6-amine 
• 1341220-51-6 (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-(benzyloxy)-4-hydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid 
• 1341220-52-7 (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-(benzyloxy)-3-hydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid 
• 1341220-53-8 (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-bis(benzyloxy)tetrahydrofuran-2-yl)methyl)thio)butanoic acid 
• 1341220-55-0 3'-benzyl-S-adenosylmethionine iodide 
• 1341220-56-1 2'-benzyl-S-adenosylmethionine iodide 
• 1341220-58-3 2',3'-benzyl-S-adenosylmethionine iodide 
• 106837-33-6 Benzyl-uronat 
• 106837-32-5 Benzyl-2,3,4-tri-O-benzyl-6-O--β-D-glucopyranosid 
• 106837-31-4 Benzyl-2,3,4-tri-O-benzyl-6-O--β-D-glucopyranosid 

Relevant articles and documents

Structure-guided design of a methyl donor cofactor that controls a viral histone H3 lysine 27 methyltransferase activity

vSET (a viral SET domain protein) is an attractive polycomb repressive complex 2 (PRC2) surrogate to study the effect of histone H3 lysine 27 (H3K27) methylation on gene transcription, as both catalyze histone H3K27 trimethylation. To control the enzymatic activity of vSET in vivo with an engineered S-adenosyl-l-methionine (SAM) analogue as methyl donor cofactor, we have carried out structure-guided design, synthesis, and characterization of orthogonal vSET methyltransferase mutant/SAM analogue pairs using a "bump-and-hole" strategy.

Process for the preparation of an oxirane, azirdine or cyclopropane

A process for the preparation of an oxirane, aziridine or cyclopropane of formula (I) wherein, X is oxygen, NR4 or CHR5 ; R1 is hydrogen, alkyl, aryl, heteroaromatic, heterocyclic or cycloalkyl; R2 is hydrogen, alkyl, aryl, heteroaromatic, CO2 R8, CHR14 NHR13, heterocyclic or cycloalkyl; or R1 and R2 join together to form a cycloalkyl ring; R3 is hydrogen, alkyl, aryl, heteroaromatic, CO2 R8, R83 Sn, CONR8 R9 or trimethylsilyl; R4 and R5 are, independently, alkyl, cycloalkyl, aryl, heteroaromatic, SO2 R8, SO3 R8, COR8, CO2 R8, CONR8 R9 or CN, or R4 can also be P(O)(aryl)2 ; R8 and R9 are independently alkyl, aryl or arylalkyl; R13 and R14 are independently hydrogen, alkyl or aryl; the process comprising reacting a mixture of a compound of formula (II), wherein R1, R2 and X are as defined above, and a sulphide of formula SR6 R7, wherein R6 and R7 are independently alkyl, aryl or heteroaomatic, or R6 and R7 join together to form a cycloalkyl ring which optionally includes an additional heteroatom, with either (i) a metallocarbon obtainable by reacting an alkylmetal with a methane derivative of formula CHR3 X'X", wherein R3 is as defined above, and X' and X" are independently, a leaving group, or (ii) a metallocarbon obtainable by reacting a compound of formula (III), (wherein R3 may not be hydrogen) with a suitable organometallic or inorganic reagent.