33758-39-3

Basic information

• Product Name: ethyl(phenyl)carbamoyl chloride
• Synonyms: ethyl(phenyl)carbamoyl chloride;Ethylphenylcarbamic acid chloride
• CAS NO: 33758-39-3
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.6348
• EINECS: 251-670-8
• Mol File: 33758-39-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 294.2°Cat760mmHg
• Flash Point: 131.7°C
• Appearance: /
• Density: 1.204g/cm³
• Vapor Pressure: 0.00164mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: ethyl(phenyl)carbamoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl(phenyl)carbamoyl chloride(33758-39-3)
• EPA Substance Registry System: ethyl(phenyl)carbamoyl chloride(33758-39-3)

Safety Data

• Hazardous Substances Data: 33758-39-3(Hazardous Substances Data)

Usage

General Description

Ethyl(phenyl)carbamoyl chloride is a chemical compound with the formula C9H10ClNO. It is an acyl chloride derivative of ethyl phenylcarbamate and is commonly used in organic synthesis as a reagent for the formation of amides and urethanes. It is a colorless liquid with a pungent odor and is highly reactive, easily forming amides with a wide range of compounds. It is a versatile and important building block in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Ethyl(phenyl)carbamoyl chloride should be handled and stored with extreme caution due to its corrosive and potentially toxic properties.

InChI:InChI=1/C9H10ClNO/c1-2-11(9(10)12)8-6-4-3-5-7-8/h3-7H,2H2,1H3

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 103-69-5 N-ethyl-N-phenylamine 
• 75-44-5 phosgene 
• 67-66-3 chloroform 

Downstream Products

• 4474-03-7 N-ethyl-N'-methyl-N,N'-diphenyl-urea 
• 64544-71-4 1-ethyl-1,3-diphenyl urea 
• 85-98-3 ethyl centralite 
• 52829-79-5 1-ethyl-1-phenyl-3-prop-2-ynyl-urea 
• 22781-48-2 4-[2-(3-Ethyl-3-phenyl-ureido)-ethyl]-benzenesulfonamide 
• 100-47-0 benzonitrile 
• 103-69-5 N-ethyl-N-phenylamine 
• 859084-57-4 ethyl-phenyl-carbamoyl azide 
• 63098-95-3 N-ethyl-N-phenyl-urea 
• 500350-60-7 N,N'-diethyl-N,N'-diphenyl-acenaphthene-5,6-dicarboxamide 
• 10045-45-1 N-ethylbenzimidazolinone 

Relevant articles and documents

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Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors

At present, inhibitors of α/β-hydrolase domain 6 (ABHD6) are viewed as a promising approach to treat inflammation and metabolic disorders. This article describes the development of 1,2,5-thiadiazole carbamates as ABHD6 inhibitors. Altogether, 34 compounds were synthesized, and their inhibitory activity was tested using lysates of HEK293 cells transiently expressing human ABHD6 (hABHD6). Among the compound series, 4-morpholino-1,2,5-thiadiazol-3-yl cyclooctyl(methyl)carbamate (JZP-430) potently and irreversibly inhibited hABHD6 (IC50 = 44 nM) and showed ～ 230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL), the main off-targets of related compounds. Additionally, activity-based protein profiling indicated that JZP-430 displays good selectivity among the serine hydrolases of the mouse brain membrane proteome. JZP-430 has been identified as a highly selective, irreversible inhibitor of hABHD6, which may provide a novel approach in the treatment of obesity and type II diabetes.

Process for the preparation of 1-4-disubstituted-5 (4H)-tetrazolinones

1,4-Disubstituted-5(4H)-tetrazolinones of the formula (I) STR1 wherein R1, R2 and R3 have the meanings given in the specification), which are known to be useful as herbicides, can be obtained in very good yields by reacting the corresponding 1-substituted-5(4H)-tetrazolinones with the corresponding carbamoyl chlorides in the presence of 4-dimethylaminopyridine.